OCULAR DOMINANCE IN LAYER-IV OF CATS VISUAL-CORTEX AND EFFECTS OF MONOCULAR DEPRIVATION
OCULAR DOMINANCE IN LAYER-IV OF CATS VISUAL-CORTEX AND EFFECTS OF MONOCULAR DEPRIVATION
复制标题
DOI：
10.1113/jphysiol.1978.sp012421
复制
发表时间：
1978-01-01
影响因子：
5.5
通讯作者：
STRYKER, MP
中科院分区：
文献类型：
--
作者：
SHATZ, CJ;STRYKER, MP
在正常猫和单眼剥夺猫的初级视觉皮层第4层，研究了眼优势生理模式与服务于每只眼睛的源性皮层传入神经的解剖分布之间的关系。一只眼睛注射了放射性标签。在足够的时间进行跨神经元运输后，进行微电极记录，并在放射自显影上定位为注射眼的源性皮层传入神经。在正常猫的第四层中，细胞根据眼睛偏好聚集，双眼驱动的细胞比其他层少。由一只眼睛主导的细胞群和由另一只眼睛主导的细胞群之间的过渡点被标记为电解损伤。在被注射的眼睛控制的细胞的位置和放射性标记的神经皮层传入事件斑块之间发现了良好的对应关系。早期长时间单眼剥夺后，第四层源性皮质传入神经的斑块比正常情况下小，而非被剥夺眼的斑块比正常情况下大。在放射性标记的传入信号斑块和注射眼主导的细胞位置之间有一个巧合。被剥夺的眼在第四层皮层细胞中占很大比例（22%）。在其他皮层中，只有7%的细胞是被剥夺的眼睛。正如猴子视觉皮层的IVc层所证明的那样，丘脑皮质投影显然是由于单眼剥夺而在物理上重新排列的（Hubel， Wiesel和LeVay）。
The relation between the physiological pattern of ocular dominance and the anatomical distribution of geniculocortical afferents serving each eye was studied in layer IV of the primary visual cortex of normal and monocularly deprived cats. One eye was injected with radioactive label. After sufficient time for transneuronal transport, micro-electrode recordings were made and the geniculocortical afferents serving the injected eye were located autoradiographically. In layer IV of normal cats, cells were clustered according to eye preference, and fewer cells were binocularly driven than in other layers. Points of transition between groups of cells dominated by one eye and those dominated by the other were marked with electrolytic lesions. A good correspondence was found between the location of cells dominated by the injected eye and the patches of radioactively labeled geniculocortical afferents. Following prolonged early monocular deprivation, the patches of geniculocortical afferents in layer IV serving the deprived eye were smaller and those serving the non-deprived eye larger than normal. There was a coincidence between the patches of radioactively labeled afferents and the location of cells dominated by the injected eye. The deprived eye dominated a substantial fraction (22%) of cortical cells in the fourth layer. In other cortical layers, only 7% of the cells were dominated by the deprived eye. The thalamocortical projection apparently is physically rearranged as a consequence of monocular deprivation as demonstrated for layer IVc of the monkey''s visual cortex (Hubel, Wiesel and LeVay).