Effect of Dietary Porphyran from the Red Alga, Porphyra yezoensis, on Glucose Metabolism in Diabetic KK-Ay Mice
Effect of Dietary Porphyran from the Red Alga, Porphyra yezoensis, on Glucose Metabolism in Diabetic KK-Ay Mice
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DOI：
10.3177/jnsv.58.14
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发表时间：
2012-02-01
影响因子：
1.6
通讯作者：
Hirata, Takashi
中科院分区：
文献类型：
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作者：
Kitano, Yuki;Murazumi, Koki;Hirata, Takashi
条斑紫菜是从红藻条斑紫菜中提取的水溶性膳食纤维。在这项研究中，我们研究了膳食POR对KK-Ay小鼠(2型糖尿病模型)糖代谢的影响。将小鼠分为4组，分别饲喂含5%纤维素(对照组)、POR、POR Arg或POR K的饲料，喂养3wk后，POR组血浆胰岛素水平和计算的稳态模型胰岛素抵抗指数(HOMA-IR)均显著低于对照组。与对照组相比，POR组、Arg组和K组的血浆脂联素水平均显著升高。这些结果表明，膳食POR可能通过上调脂联素水平来改善糖尿病患者的糖代谢。此外，POR组盲肠中丙酸的含量显著高于对照组，日粮For改变了盲肠菌群的分布。与对照组相比，POR、POR Arg和POR K组盲肠中类杆菌明显增多，球状芽孢杆菌显著减少。日粮POR对后肠环境的影响可能有助于改善糖代谢。
Porphyran (FOR) from the red alga Porphyra yezoensis is a water soluble dietary fiber. In this study, we investigated the effect of dietary POR on glucose metabolism in KK-Ay mice (a model for type 2 diabetes). Mice were divided into 4 groups and fed a diet containing 5% cellulose (control), POR, POR Arg or POR K. After 3 wk of feeding, plasma insulin levels and the calculated homeostasis model assessment-insulin resistance (HOMA-IR) index were significantly lower in the POR group than in the control group. Compared with the control group, plasma adiponectin levels were significantly increased in the POR, FOR Arg and FOR K groups. These results suggest that dietary POR should improve glucose metabolism in diabetes via up-regulation of adiponectin levels. In addition, the amount of propionic acid in the cecum of the POR group was significantly higher than in the control group and the profile of bacterial flora was changed by dietary FOR. In the cecum of the POR, POR Arg and POR K groups, Bacteroides was significantly increased and Clostridium coccoides was significantly decreased compared with in the control group. The effects of dietary POR on the hindgut environment might contribute to the improvement of glucose metabolism.