Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination
Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination
复制标题
DOI：
10.1016/s0165-0270(02)00012-2
复制
发表时间：
2002-04-15
影响因子：
3
通讯作者：
Whishaw, IQ
中科院分区：
文献类型：
--
作者：
Metz, GA;Whishaw, IQ
梯子横档行走测试是一项新的任务，用于评估熟练行走以及测量前肢和后肢的放置、迈步和肢体间的协调。大鼠会自发地从起始位置沿着水平梯子走向目标。梯子横档之间的间距是可变的，可以改变以防止动物记住横档的绝对或相对位置。该测试程序所需的训练极少，并允许使用视频记录进行详细的定量和定性分析。通过对因运动皮层软脑膜剥离造成单侧新皮质卒中的动物、在锥体束处切断束路造成新生儿和成年单侧皮质脊髓束损伤的动物以及向黑质纹状体束注射6 - 羟多巴胺造成单侧多巴胺耗竭的动物所获得的术后数据，描述了该测试的实用性。此外，还对一组老年大鼠进行了检查。动物表现出的肢体放置、迈步和协调方面的缺陷表明，该测试能够区分运动系统损伤或与年龄相关的损伤。该测试对于评估因脑或脊髓损伤导致的功能丧失和恢复、治疗方法的有效性以及动物适应神经系统损伤的代偿过程是有用的。（C）2002年由爱思唯尔科学出版社出版
The ladder rung walking test is a new task to assess skilled walking and measure both forelimb and hindlimb placing, stepping, and inter-limb co-ordination. Rats spontaneously walk from a starting location to a goal along a horizontal ladder. The spacing between the rungs of the ladder is variable and can be changed to prevent the animal from learning either the absolute or relative location of the rungs. The testing procedure requires minimal training and allows detailed quantitative and qualitative analysis using video recording. The utility of the test is described with postoperative data obtained from animals with unilateral neocortical strokes produced by pial stripping over the motor cortex, neonatal and adult unilateral corticospinal tract lesions produced by tract section at the pyramids, and unilateral dopamine depletions produced by injection of 6-hydroxydopamine into the nigrostriatal bundle. In addition, a group of aged rats was examined. Deficits in limb placing, stepping and co-ordination displayed by the animals demonstrate that this test can discriminate between lesions of the motor system or age-associated impairments. The test is useful for assessing loss and recovery of function due to brain or spinal cord injury. the effectiveness of treatment therapies, as well as compensatory processes through which animals adapt to nervous system injury. (C) 2002 Published by Elsevier Science B.V.