Recent advances in understanding the role of the hypothalamic circuit during aggression.
Recent advances in understanding the role of the hypothalamic circuit during aggression.
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DOI：
10.3389/fnsys.2014.00168
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发表时间：
2014
影响因子：
3
通讯作者：
Lin D
中科院分区：
文献类型：
--
作者：
Falkner AL;Lin D
大约在世纪前，下丘脑首次与经典的“战或逃”反应有关，从那时起，人们在理解这些行为产生的电路和神经动力学方面取得了许多重要进展。在这篇综述中，我们将重点关注下丘脑在攻击中的作用，特别注意该领域的最新进展，允许相关的下丘脑亚核的功能鉴定。这一领域的最新进展得益于功能操纵新技术的发展，包括光遗传学和药物遗传学，以及复杂社会行为期间用于长期体内记录的技术的进步。我们将通过（1）功能丧失研究，包括药理学和药物遗传学;（2）功能获得研究，包括经典电刺激研究结果与最近使用光遗传学的研究结果之间的具体比较;和（3）神经活动，包括立即早期基因和清醒行为记录。最后，我们将概述目前的方法来确定下丘脑在促进攻击性动机和攻击性行动的确切作用。
The hypothalamus was first implicated in the classic “fight or flight” response nearly a century ago, and since then, many important strides have been made in understanding both the circuitry and the neural dynamics underlying the generation of these behaviors. In this review, we will focus on the role of the hypothalamus in aggression, paying particular attention to recent advances in the field that have allowed for functional identification of relevant hypothalamic subnuclei. Recent progress in this field has been aided by the development of new techniques for functional manipulation including optogenetics and pharmacogenetics, as well as advances in technology used for chronic in vivo recordings during complex social behaviors. We will examine the role of the hypothalamus through the complimentary lenses of (1) loss of function studies, including pharmacology and pharmacogenetics; (2) gain of function studies, including specific comparisons between results from classic electrical stimulation studies and more recent work using optogenetics; and (3) neural activity, including both immediate early gene and awake-behaving recordings. Lastly, we will outline current approaches to identifying the precise role of the hypothalamus in promoting aggressive motivation and aggressive action.