Clinical and functional ultra-long-term outcome of patients with a clinical high risk (CHR) for psychosis
Clinical and functional ultra-long-term outcome of patients with a clinical high risk (CHR) for psychosis
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DOI：
10.1016/j.eurpsy.2019.08.005
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发表时间：
2019-10-01
影响因子：
7.8
通讯作者：
Riecher-Rossler, Anita
中科院分区：
文献类型：
--
作者：
Beck, Katharina;Studerus, Erich;Riecher-Rossler, Anita
背景：很少有研究对精神病临床高危患者进行超过2-3年的随访。我们的目的是调查在长达16年的随访期内，从精神分裂症缓解和向精神病转变的比率和基线预测因素。此外，我们研究的临床和功能的长期结果的pneumatic patients谁没有transition.Methods：我们分析了长期过程中的pneumatic patients已被列入纵向研究“Fruherkennung冯Psychosed”（FePsy）或“Bruderholz”（BHS）。那些在最初的随访期（2/5年）内没有转变为精神病的患者被邀请进行额外的随访。结果：最初，纳入了255名CHR患者。其中，47人在最初的随访中转变为精神病。因此，联系了208例患者进行长期随访，其中72例（34.6%）参与。在最初的255例样本中，估计分别有26%、31%、35%和38%在3年、5年、10年和16年后转变，51%在最近的随访中从高风险状态缓解。基线时较好的心理社会功能与较高的缓解率相关。在长期随访中重新评估的72例患者中，有60例没有过渡，但只有28%的人完全恢复临床和functional.Conclusions：我们的研究表明，需要随访和临床关注的时间比通常的2-3年，因为有几个过渡期较晚的患者，只有少数没有过渡期的患者完全恢复。(C)2019 Elsevier Masson SAS。All rights reserved.
Background: Few studies have followed up patients with a clinical high risk (CHR) for psychosis for more than 2-3 years. We aimed to investigate the rates and baseline predictors for remission from CHR and transition to psychosis over a follow-up period of up to 16 years. Additionally, we examined the clinical and functional long-term outcome of CHR patients who did not transition.Methods: We analyzed the long-term course of CHR patients that had been included in the longitudinal studies "Fruherkennung von Psychosen" (FePsy) or "Bruderholz" (BHS). Those patients who had not transitioned to psychosis during the initial follow-up periods (2/5 years), were invited for additional follow-ups.Results: Originally, 255 CHR patients had been included. Of these, 47 had transitioned to psychosis during the initial follow-ups. Thus, 208 were contacted for the long-term follow-up, of which 72 (34.6%) participated. From the original sample of 255, 26%, 31%, 35%, and 38% were estimated to have transitioned after 3, 5, 10, and 16 years, respectively, and 51% had remitted from their high risk status at the latest follow-up. Better psychosocial functioning at baseline was associated with a higher rate of remission. Of the 72 CHR patients re-assessed at long-term follow-up, 60 had not transitioned, but only 28% of those were fully recovered clinically and functionally.Conclusions: Our study shows the need for follow-ups and clinical attention longer than the usual 2-3 years as there are several CHR patients with later transitions and only a minority of CHR those without transition fully recovers. (C) 2019 Elsevier Masson SAS. All rights reserved.