Maintenance and manipulation in spatial working memory:: Dissociations in the prefrontal cortex
Maintenance and manipulation in spatial working memory:: Dissociations in the prefrontal cortex
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DOI：
10.1006/nimg.2002.1161
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发表时间：
2002-09-01
期刊：
影响因子：
5.7
通讯作者：
Cannon, TD
中科院分区：
文献类型：
--
作者：
Glahn, DC;Kim, J;Cannon, TD
通过两个实验对人类前额叶皮质空间工作记忆的功能组织理论进行了比较。在实验1中，不同位置的记忆集大小是参数不同的，允许评估不同维护要求的粗体信号。在第二个实验中，对保存在工作记忆中的空间信息的操作与对该信息的简单维护进行了对比。这两个实验都在分布式空间工作记忆网络中引发了显著的活动。虽然背外侧前额叶激活随着记忆集大小的增加而单调增加，但该区域在涉及对内部表征的外显操作的任务条件下具有不同的参与。额上沟区的激活与空间信息的维持有关，并随着记忆集大小的增加而增加。相比之下，腹外侧前额叶激活只出现在最大记忆集大小，可能是由于组织策略与更复杂的刺激的不同使用。这些结果支持背外侧前额叶皮质参与内部表征的操纵和额上沟区参与空间信息的维持的说法，但它们表明腹外侧额前区起着复杂的作用。(C)2002年埃尔塞维尔科学公司(美国)。
Two experiments were conducted to compare theories of the functional organization of spatial working memory within the human prefrontal cortex. In Experiment 1, memory set size for locations was parametrically varied, allowing for the assessment of BOLD signal across maintenance requirements. In the second experiment, manipulation of spatial information held in working memory was contrasted with simple maintenance of that information. Both experiments evoked significant activity in a distributed spatial working memory network. Although dorsolateral prefrontal activation increased monotonically with memory set size, this region was differentially engaged in task conditions involving explicit manipulation of internal representations. Activation in the superior frontal sulcal region was associated with maintenance of spatial information, increasing with memory set size. In contrast, ventrolateral prefrontal activation was present only at the highest memory set size, possibly due to the differential use of organizational strategies with more complex stimuli. These results support claims that the dorsolateral prefrontal cortex is involved in the manipulation of internal representations and that the superior frontal sulcal region is involved in the maintenance of spatial information, but they suggest a complex role for the ventrolateral prefrontal region. (C) 2002 Elsevier Science (USA).