Mechanism-based inhibition of zinc proteases
Mechanism-based inhibition of zinc proteases
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DOI：
10.2174/0929867013372805
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发表时间：
2001-07-01
影响因子：
4.1
通讯作者：
Mobashery, S
中科院分区：
文献类型：
--
作者：
Kim, DH;Mobashery, S
锌蛋白酶的功能与生物体的许多生理和病理过程有关。基于机制的抑制剂作为在靶向特定酶方面提供高选择性的生物活性分子受到高度追捧。在过去的几年中，已经开发了锌依赖性蛋白酶的基于机制的抑制剂。这些抑制剂在其酶抑制机制中利用了过渡金属固有的化学性质。这些努力已在本手稿中进行了审查。
The functions of zinc proteases have been implicated in a host of physiological and pathological processes in living organisms. Mechanism-based inhibitors are highly sought as biologically active molecules that afford high selectivity in targeting specific enzymes. Mechanism-based inhibitors for zinc-dependent proteases have been developed in the past several years. These inhibitors exploit the chemistry inherent to transition metals in their mechanisms of enzyme inhibition. These efforts have been reviewed in this manuscript.