Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus
Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus
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DOI：
10.1021/acs.jnatprod.8b01086
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发表时间：
2019-05-01
影响因子：
5.1
通讯作者：
Stadler, Marc
中科院分区：
文献类型：
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作者：
Cheng, Tian;Chepkirui, Clara;Stadler, Marc
在从肯尼亚担子菌中寻找新的抗感染药物和其他生物活性次生代谢物的过程中，发现了 13 种以前未描述的代谢物，(6R,7S,10R)-7,10-环氧-7,11-二甲基十二-1-烯-6,11-二醇 (1) 和 12 种名为 elgonenes A-L (2-13) 的倍半萜，以及已知化合物对香豆酸 (14) 是从埃尔贡山自然保护区收集的担子菌中分离出来的。该生产生物代表了桑黄孢属的一个新种，它是重要的传统亚洲药用蘑菇的分离品种之一，以前被称为“桦褐孔菌”复合体。报道了基于二维核磁共振波谱、高分辨率质谱和其他光谱方法的化合物1-13的结构解析，以及它们的抗菌、抗真菌和细胞毒活性。
During the course of searching for new anti infective and other biologically active secondary metabolites from Kenyan basidiomycetes, 13 previously undescribed metabolites, (6R,7S,10R)-7,10-epoxy-7,11-dimethyldodec-1-ene-6,11-diol (1) and 12 sesquiterpenes named elgonenes A-L (2-13), and the known compound P-coumaric acid (14) were isolated from a basidiomycete collected in Mount Elgon Natural Reserve. The producing organism represents a new species of the genus Sanghuangporus, which is one of the segregates of the important traditional Asian medicinal mushrooms that were formerly known as the "Inonotus linteus" complex. The structure elucidation of compounds 1-13, based on 2D NMR spectroscopy, high resolution mass spectrometry, and other spectral methods, and their antibacterial, antifungal, and cytotoxic activities are reported.