Gender does not influence the susceptibility of C57BL/6 mice to develop chronic experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein
Gender does not influence the susceptibility of C57BL/6 mice to develop chronic experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein
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DOI：
10.1016/s0165-2478(01)00339-x
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发表时间：
2002-04-01
影响因子：
4.4
通讯作者：
Bernard, CCA
中科院分区：
文献类型：
--
作者：
Okuda, Y;Okuda, M;Bernard, CCA
多发性硬化症（MS）是一种中枢神经系统（CNS）的炎性脱髓鞘疾病，女性比男性更常见。实验性自身免疫性脑脊髓炎（experimental autoimmune encephalomyelitis，EAE）是一种由髓鞘碱性蛋白或蛋白脂质蛋白诱导的多发性硬化症（MS）模型。与此相反，我们在这里报告，没有显着差异，雌性小鼠和雄性小鼠与髓鞘少突胶质细胞糖蛋白（MOG）诱导的EAE的发病率观察。临床过程CNS中的组织学发现、T细胞应答和脾细胞对MOG的细胞因子产生。血清抗MOG IgG水平。提示EAE的性别差异与致脑炎原和动物品系有关。鉴于MOG是MS中假定的致病性髓鞘抗原，本研究结果可能对该疾病的发病机制有影响。(C)2002 Elsevier Science B.V.保留所有权利。
Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), is more prevalent in females than males. It is well documented that a significant gender difference exits in the susceptibility I of mice to develop experimental autoimmune encephalomyelitis (EAE), a model of MS. induced by myelin basic protein or proteolipid protein. In contrast, we report here that no significant difference between female mice and male mice with myelin oligodendrocyte glycoprotein (MOG)-induced EAE was observed in the incidence of disease. clinical course. histological findings in the CNS, T cell response and cytokine production of spleen cells to MOG. and anti-MOG IgG level in serum. These results Suggest that gender-related difference in EAE depends on the encephalitogen and,or the strain of animals used. Given that MOG is a putative pathogenic myelin antigen in MS. the present Findings may have implications for the pathogenesis of this disease. (C) 2002 Elsevier Science B.V. All rights reserved.