Transcellular route of diffusion through stratum corneum: Results from finite element models
Transcellular route of diffusion through stratum corneum: Results from finite element models
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DOI：
10.1002/jps.20695
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发表时间：
2006-10-01
影响因子：
3.8
通讯作者：
Frasch, H. Frederick
中科院分区：
文献类型：
--
作者：
Barbero, Ana M.;Frasch, H. Frederick
通过将渗透性和滞后时间 (t(lag)) 的实验测量值与有限元 (FE) 模型的预测进行比较，可以深入了解亲水性化合物的角质层 (SC) 渗透途径。根据文献编制了亲水化合物的渗透性和滞后时间测量（n = 27）的数据库。跨细胞和横向脂质扩散途径是在代表完全水合的人类 SC 的实体几何结构中建模的。脂质途径的模型 t(lag) 太短，无法解释实验量，而具有优先角质细胞分配的跨细胞途径确实可以解释它们。测得的 Hag 与化合物的辛醇-水分配系数高度相关 (p < 0.0001)，支持亲水化合物渗透中水-脂质分配机制的假设。证明了延迟时间对于识别扩散途径的重要性。 (c) 2006 Wiley-Liss, Inc.
Insight into the stratum corneum (SC) permeation pathway for hydrophilic compounds is gained by comparing experimental measurements of permeability and lag time (t(lag)) with the predictions of a finite element (FE) model. A database of permeability and lag time measurements (n = 27) of hydrophilic compounds was compiled from the literature. Transcellular and lateral lipid diffusion pathways were modeled within a brick-and-mortar geometry representing fully hydrated human SC. Modeled t(lag)'s for the lipid pathway are too brief to account for the experimental quantities, whereas the transcellular pathway with preferential corneocyte partitioning does account for them. Measured Hag's are highly correlated (p < 0.0001) with the compound's octanol-water partition coefficient, supporting the hypothesis of an aqueous-lipid partition mechanism in the permeation of hydrophilic compounds. The importance of the lag time for identifying the diffusion pathway is demonstrated. (c) 2006 Wiley-Liss, Inc.