Enrollment in a brain magnetic resonance study: Results from the women's health initiative memory study magnetic resonance imaging study (WHIMS-MRI)
Enrollment in a brain magnetic resonance study: Results from the women's health initiative memory study magnetic resonance imaging study (WHIMS-MRI)
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DOI：
10.1016/j.acra.2007.02.001
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发表时间：
2007-05-01
影响因子：
4.8
通讯作者：
Espeland, Mark A.
中科院分区：
文献类型：
--
作者：
Jaramillo, Sarah A.;Felton, Deborah;Espeland, Mark A.
理由和目标。脑磁共振成像（MRI）研究的志愿者入组率因人口统计学和临床特征而异。我们使用一个大型MRI研究的数据，以确定与差异入组相关的因素，并检查潜在的偏见，这可能会产生的研究结果。结果招募1,431名妇女的MRI子研究的妇女健康倡议记忆研究（WHIMS-MRI）进行了说明。进行敏感性分析以估计与风险因素关系估计的缺失数据相关的偏差程度。结果。在2,345名来自70岁以上的女性队列的女性中，72%的人同意接受WHIMS-MRI筛查。最终扫描完成率为61%。完成率根据可能与研究结局相关的一系列社会人口统计学、生活方式和临床特征而变化。磁共振成像研究中合理水平的选择性入组可能会在风险因素关系的描述中产生中度偏倚（< +/- 20%）。不良事件，如幽闭恐怖症，发生在1.7%的尝试扫描，并在0.8%的情况下，导致数据丢失。老年妇女入组脑成像研究是可行的，尽管选择偏差可能会限制研究队列如何更好地反映更一般的人群。
Rationale and Objectives. The rates of enrollment of volunteers for brain magnetic resonance imaging (MRI) studies vary by demographic and clinical characteristics. We use data from a large MRI study to identify factors associated with differential enrollment and to examine potential biases this may produce in study results.Materials and Methods. Results from recruitment of 1,431 women into the MRI substudy of the Women's Health Initiative Memory Study (WHIMS-MRI) are described. A sensitivity analysis was conducted to estimate the degree of bias associated with missing data on estimates of risk factor relationships.Results. Of 2,345 women contacted from an established cohort of women older than 70 years of age, 72% consented to undergo screening for WHIMS-MRI. Scanning was ultimately completed on 61 %. Completion rates varied according to a range of sociodemographic, lifestyle, and clinical characteristics that may be related to study outcomes. Plausible levels of selective enrollment in magnetic resonance imaging studies may produce moderate biases (< +/- 20%) in characterizations of risk factor relationships. Adverse events, such as claustrophobia, occurred during 1.7% of the attempted scans and, in 0.8% of instances, led to lost data.Conclusions. Enrollment of older women into brain imaging studies is feasible, although selection biases may limit how well study cohorts reflect more general populations.