Differences between males and females in rates of serotonin synthesis in human brain
Differences between males and females in rates of serotonin synthesis in human brain
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DOI：
10.1073/pnas.94.10.5308
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发表时间：
1997-05-13
影响因子：
11.1
通讯作者：
Diksic, M
中科院分区：
文献类型：
--
作者：
Nishizawa, S;Benkelfat, C;Diksic, M
使用正电子发射断层扫描测量人脑中血清素的合成率。该方法的灵敏度表明，即使在色氨酸急性消耗导致合成大幅降低后，仍然可以进行测量。与人脑中不同脑区的血清素水平差异很大，吲哚胺的合成率在整个大脑中相当一致。发现正常男性的平均合成率比正常女性高 52%；这种显着差异可能是男性重度单相抑郁症发病率较低的一个因素。
Rates of serotonin synthesis were measured in the human brain using positron emission tomography. The sensitivity of the method is indicated by the fact that measurements are possible even after a substantial lowering of synthesis induced by acute tryptophan depletion, Unlike serotonin levels in human brain, which vary greatly in different brain areas, rates of synthesis of the indolamine are rather uniform throughout the brain, The mean rate of synthesis in normal males was found to be 52% higher than in normal females; this marked difference may be a factor relevant to the lower incidence of major unipolar depression in males.