Effects of polymethylmethacrylate nanoplastics on Dicentrarchus labrax
Effects of polymethylmethacrylate nanoplastics on Dicentrarchus labrax
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DOI：
10.1016/j.ygeno.2018.10.006
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发表时间：
2018-11-01
期刊：
影响因子：
4.4
通讯作者：
Oliveira, M.
中科院分区：
文献类型：
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作者：
Brandts, I;Teles, M.;Oliveira, M.
本研究旨在评估短期暴露后类似于45 nm的纳米塑料（NPs）对海鱼Dicentrarchus labrax的影响。将动物暴露于一定浓度范围的NP 96小时，并对肝脏、血浆和皮肤粘液取样。评估的终点包括生化生物标志物和与脂质代谢、免疫系统和一般细胞应激相关的基因表达。与脂代谢相关的mRNA转录产物ppara和ppary的表达量在NPs暴露后显著增加。生化终点显示血浆中酯酶活性水平降低，表明鱼类的免疫系统可能会受到NPs暴露的损害。此外，在暴露于NP的动物的皮肤粘液中发现碱性磷酸酶的水平显著较低。目前的研究结果表明，纳米颗粒可能对这种海洋鱼类造成危害，可能会干扰脂质代谢和免疫反应的正确功能。
The present study aimed to evaluate the effects of similar to 45 nm nanoplastics (NPs) on the marine fish Dicentrarchus labrax after a short-term exposure. Animals were exposed to a concentration range of NPs for 96 h and liver, plasma and skin mucus were sampled. Assessed endpoints included biochemical biomarkers and expression of genes related to lipid metabolism, immune system and general cell stress. Abundance of mRNA transcripts related to lipid metabolism, ppara and ppary, were significantly increased after exposure to NPs. Biochemical endpoints revealed decreased esterase activity levels in plasma, suggesting that the immune system of fish might be compromised by exposure to NPs. Moreover, significantly lower levels of alkaline phosphatase were found in the skin mucus of animals exposed to NPs. The present results suggest that NPs may represent a hazard to this marine fish, potentially interfering with the metabolism of lipids and the correct function of the immune response.