Relationship between Paraoxonase 1 (PON1) gene polymorphisms and susceptibility of stroke: a meta-analysis
Relationship between Paraoxonase 1 (PON1) gene polymorphisms and susceptibility of stroke: a meta-analysis
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DOI：
10.1007/s10654-010-9470-4
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发表时间：
2010-07-01
影响因子：
13.6
通讯作者：
Banerjee, Indranil
中科院分区：
文献类型：
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作者：
Banerjee, Indranil
对氧磷酶1（PON1）的遗传变异在几项病例对照关联研究中与卒中易感性有关。然而，这些研究报告了明显相互矛盾的结果，使精确评估与变异相关的疾病风险变得困难。因此，通过纳入研究PON1基因编码区两种常见多态性（L55M和Q192R）与卒中风险之间的关联进行荟萃分析。共纳入10项L55M多态性研究和11项Q192R多态性研究。结果显示，尽管55L等位基因与脑卒中无显著关联[随机效应OR = 1.09，95%CI（0.93，1.27），P = 0.29]，192R等位基因在整个研究人群中赋予显著的卒中风险[随机效应OR = 1.25，95%CI（1.07，1.46），P = 0.006]。纯合子对照和显性、隐性和加性模型的结果与等位基因对照相同。对卒中类型、患者年龄和种族的亚组分析显示，55 L等位基因与卒中无关联，而192 R等位基因的关联在包括缺血性卒中患者、平均年龄> 60岁的卒中患者和高加索受试者的组中显著持续。但在东亚人群中未检测到该等位基因与卒中易感性的显著关联。因此，本荟萃分析的结果表明，Q192R多态性可能是脑卒中的重要危险因素，尤其是在高加索人群中。
Genetic variants of paraoxonase 1 (PON1) were implicated in stroke susceptibility in several case-control association studies. However, the studies have reported apparently conflicting results, rendering precise assessment of the disease risk associated with the variants difficult. A meta-analysis was therefore conducted by including the studies that examined the association between two common polymorphisms (L55M and Q192R) in the coding region of PON1 gene and the risk of stroke. Altogether 10 studies on L55M polymorphism and 11 studies on Q192R polymorphism were included in this meta-analysis. The results showed, although there was no significant association of the 55L allele with stroke [random effects OR = 1.09, 95% CI (0.93, 1.27), P = 0.29], the 192R allele conferred significant risk of stroke in the overall study population [random effects OR = 1.25, 95% CI (1.07, 1.46), P = 0.006]. Same pattern of results as both the allele contrasts was obtained for the homozygote contrasts and the dominant, recessive and additive models. Subgroup analyses for stroke type, age of patients and ethnicity revealed no association of the 55L allele with stroke, whereas the association of the 192R allele persisted significantly in the groups comprising ischemic stroke patients, stroke patients with mean age > 60 years and Caucasian subjects. But no significant association of this allele with stroke susceptibility was detected in the East Asian population. Therefore, the results of this meta-analysis indicate, the Q192R polymorphism could be an important risk factor for stroke, especially in the Caucasian population.