THE OCCURRENCE OF SLEEP-DISORDERED BREATHING AMONG MIDDLE-AGED ADULTS
THE OCCURRENCE OF SLEEP-DISORDERED BREATHING AMONG MIDDLE-AGED ADULTS
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DOI：
10.1056/nejm199304293281704
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发表时间：
1993-04-29
影响因子：
158.5
通讯作者：
BADR, S
中科院分区：
文献类型：
--
作者：
YOUNG, T;PALTA, M;BADR, S
背景。有限的数据表明，成年人普遍存在睡眠呼吸，睡眠期间呼吸暂停和呼吸症的重复发作的状况。威斯康星州睡眠队列研究的数据是对心肺疾病的自然史的一项纵向研究，用于估计成年人中未诊断的睡眠呼吸呼吸的流行，并解决了其对公共卫生的重要性。通过隔夜多聚会学研究了30至60岁的602名男性和女性的随机样本，以确定呼吸暂停和呼吸症的呼吸症发作频率（呼吸暂停-Hypopnea评分）。我们使用呼吸暂停分数的三个截止点（大于或等于5，超过或等于10），测量了该组睡眠呼吸的年龄和性别特异性患病率，并且比15）;我们使用逻辑回归来研究风险因素。估计的睡眠呼吸呼吸的患病率定义为5或更高的呼吸暂停评分，女性为9％，男性为24％，我们估计中年劳动力中有2％的女性和4％的男性符合睡眠呼吸暂停综合征的最低诊断标准（呼吸暂停评分为5或更高和白天的高血压）。男性和肥胖与呼吸困难的呼吸密切相关。男性和女性的习惯性打s，呼吸呼吸暂停评分的患病率较高，为15或更高。男性中未诊断的睡眠呼吸呼吸的流行率很高，并且比以前怀疑的女性高得多。未诊断的睡眠呼吸呼吸与白天的高血压有关。
Background. Limited data have suggested that sleep-disordered breathing, a condition of repeated episodes of apnea and hypopnea during sleep, is prevalent among adults. Data from the Wisconsin Sleep Cohort Study, a longitudinal study of the natural history of cardiopulmonary disorders of sleep, were used to estimate the prevalence of undiagnosed sleep-disordered breathing among adults and address its importance to the public health.Methods. A random sample of 602 employed men and women 30 to 60 years old were studied by overnight polysomnography to determine the frequency of episodes of apnea and hypopnea per hour of sleep (the apnea-hypopnea score). We measured the age- and sex-specific prevalence of sleep-disordered breathing in this group using three cutoff points for the apnea-hypopnea score (greater-than-or-equal-to 5, greater-than-or-equal-to 10, and greater-than-or-equal-to 15); we used logistic regression to investigate risk factors.Results. The estimated prevalence of sleep-disordered breathing, defined as an apnea-hypopnea score of 5 or higher, was 9 percent for women and 24 percent for men We estimated that 2 percent of women and 4 percent of men in the middle-aged work force meet the minimal diagnostic criteria for the sleep apnea syndrome (an apnea-hypopnea score of 5 or higher and daytime hypersomnolence). Male sex and obesity were strongly associated with the presence of sleep-disordered breathing. Habitual snorers, both men and women, tended to have a higher prevalence of apnea-hypopnea scores of 15 or higher.Conclusions. The prevalence of undiagnosed sleep-disordered breathing is high among men and is much higher than previously suspected among women. Undiagnosed sleep-disordered breathing is associated with daytime hypersomnolence.