Dynamics of genetic code evolution: The emergence of universality

Dynamics of genetic code evolution: The emergence of universality
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DOI:
10.1101/779959
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发表时间:
2019-09
期刊:
bioRxiv
影响因子:
--
通讯作者:
J. Argyriadis;Yang-Hui He;Vishnu Jejjala;D. Minic
J. Argyriadis;Yang-Hui He;Vishnu Jejjala;D. Minic
中科院分区:
其他
文献类型:
--
作者:
J. Argyriadis;Yang-Hui He;Vishnu Jejjala;D. Minic

文献摘要

相似文献

我们研究遗传密码进化的动力学。Vetsigian等人提出的算法。[1]提供了一种既优化又通用的解决方案。我们将该算法作为一个动态系统进行再现和分析。模型中使用的所有参数都是不同的,以评估它们对实现普遍性的影响。我们证明,通过允许特定参数随时间变化,该算法收敛得更快,以获得一个通用的解。最后,我们研究了由该模型引起的遗传密码的自同构。我们利用这一点来检查解决方案的规模,以了解普适性的起源,并发现有一个直接的联系突变率。
We study the dynamics of genetic code evolution. The algorithm of Vetsigian et al. [1] provides a solution that is both optimal and universal. We reproduce and analyze the algorithm as a dynamical system. All the parameters used in the model are varied to assess their impact on achieving universality. We show that by allowing specific parameters to vary with time, the algorithm converges much faster to a universal solution. Finally, we study automorphisms of the genetic code arising due to this model. We use this to examine the scaling of the solutions in order to understand the origin of universality and find that there is a direct link to mutation rate.