Development of closed-loop neural interface technology in a rat model: combining motor cortex operant conditioning with visual cortex microstimulation.
Development of closed-loop neural interface technology in a rat model: combining motor cortex operant conditioning with visual cortex microstimulation.
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DOI：
10.1109/tnsre.2010.2041363
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Kipke DR
中科院分区：
文献类型：
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作者：
Marzullo TC;Lehmkuhle MJ;Gage GJ;Kipke DR
假设将神经整体解码与同步电微刺激反馈相结合的闭环神经接口技术可以改善深部脑刺激技术、神经运动假体应用和癫痫治疗。在这里，我们描述了我们在感觉和运动神经生理反馈控制系统的大鼠模型中的迭代结果。三只老鼠的运动皮层和视觉皮层都长期植入微电极阵列。随后，对大鼠进行了数周的训练，通过对视觉皮层进行皮层内微刺激（ICMS）来调节其运动皮层整体单元的活动，以获得食物奖励。在代表运动皮层整体动态的反应期间，通过视觉皮层 ICMS 向大鼠提供连续反馈。分析显示，反馈为动物提供了行为试验的指标。在硬件层面，这种准备工作为改进闭环神经设备技术提供了一个易于处理的测试模型。
Closed-loop neural interface technology that combines neural ensemble decoding with simultaneous electrical microstimulation feedback is hypothesized to improve deep brain stimulation techniques, neuromotor prosthetic applications, and epilepsy treatment. Here we describe our iterative results in a rat model of a sensory and motor neurophysiological feedback control system. Three rats were chronically implanted with microelectrode arrays in both the motor and visual cortices. The rats were subsequently trained over a period of weeks to modulate their motor cortex ensemble unit activity upon delivery of intra-cortical microstimulation (ICMS) of the visual cortex in order to receive a food reward. Rats were given continuous feedback via visual cortex ICMS during the response periods that was representative of the motor cortex ensemble dynamics. Analysis revealed that the feedback provided the animals with indicators of the behavioral trials. At the hardware level, this preparation provides a tractable test model for improving the technology of closed-loop neural devices.