Selective Dual-Channel Imaging on Cyanostyryl-Modified Azulene Systems with Unimolecularly Tunable Visible-Near Infrared Luminescence.
Selective Dual-Channel Imaging on Cyanostyryl-Modified Azulene Systems with Unimolecularly Tunable Visible-Near Infrared Luminescence.
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DOI：
10.1002/chem.201700947
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Yunyun Zhou;Yaping Zhuang;Xin Li;H. Ågren;Lin Yu;Jiandong Ding;Liangliang Zhu
中科院分区：
文献类型：
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作者：
Yunyun Zhou;Yaping Zhuang;Xin Li;H. Ågren;Lin Yu;Jiandong Ding;Liangliang Zhu
虽然有机发光分子在现代生物成像科学中受到越来越多的关注和应用，但单分子选择性成像中复杂光致发光特性的设计和控制仍然是一个具有挑战性的课题。考虑到可调多途径成像可以与治疗过程中的治疗过程紧密相连，进行了将甘菊环和氰基苯乙烯基部分整合到一个骨架中以产生原位刺激响应性发光材料，目的是通过单分子平台上的智能分子设计在不同通道中实现可调和有效的发射。该策略利用了1）氰基苯乙烯基单元的Z/E异构化，其可以改变取代对甘菊环的推拉效应，伴随着改变单个激发态的吸收和发射，以及2）优化的激发态调节，用于打开近红外发射通道，并与可见光发射的利用一起弥补可控的双路发光系统。如通过在细胞水平操纵发光的演示所例示的，该材料表现出单分子选择性成像、标记和探测事件的上级应用潜力。
Although organic light-emitting molecules have received a growing attention and applicability in modern bioimaging science, the design and control of complex photoluminescent properties in unimolecularly selective imaging remains a challenging topic. Considering that tunable multipathway imaging can be advantagedly connected with treatment processes in therapy, the integration of an azulene and a cyanostyryl moiety into one skeleton is carried out for the generation of in situ stimuli-responsive luminescent materials, with the aim to achieve tunable and effective emissions in distinct channels through smart molecular design on a single-molecular platform. This strategy takes advantage of 1) the Z/E isomerization of the cyanostyryl unit that can vary the push-pull effect of the substitution on azulene, accompanied by altering absorption and emission of individual excited states, and 2) an optimized excited-state regulation for opening a near infrared emissive channel and making up for a controllable dual-pathway luminescent system together with the utilization of visible emission. As exemplified by a demonstration of manipulating the luminescence at the cell level, the materials exhibit a superior application potential for unimolecularly selective imaging, labeling and probing events.