Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in a Rehabilitation Facility: Evolution of the Presence of Nasopharyngeal SARS-CoV-2 and Serological Antibody Responses.
Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in a Rehabilitation Facility: Evolution of the Presence of Nasopharyngeal SARS-CoV-2 and Serological Antibody Responses.
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DOI：
10.1093/infdis/jiaa610
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发表时间：
2021-02-03
期刊：
影响因子：
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通讯作者：
Fertleman M
中科院分区：
文献类型：
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作者：
Harris BHL;Zuhair M;Di Giovannantonio M;Rosadas C;Khan M;Short CE;Thaventhiran T;Quinlan R;Taylor A;Calvez R;Taylor GP;Tedder RS;McClure MO;Fertleman M
在英国 2019 年冠状病毒病流行之初，这项罕见的点流行率研究显示，伦敦一家住院康复中心的患者（45 名患者中的 15 名）被发现感染了严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2)，但无症状。我们详细报告了 8 名患者，包括他们的临床稳定性、鼻咽病毒逆转录聚合酶链反应 (RT-PCR) 负担的演变以及随时间变化的抗体水平，通过 RT-PCR 和血清学揭示了急性期的感染动态。值得注意的是，针对 SARS-CoV-2 受体结合域的抗体的新型血清学测试表明，我们的无症状队列中 100% 的人在诊断后 3-6 周仍保持血清阳性。
At the start of the UK coronavirus disease 2019 epidemic, this rare point prevalence study revealed that one-third of patients (15 of 45) in a London inpatient rehabilitation unit were found to be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but asymptomatic. We report on 8 patients in detail, including their clinical stability, the evolution of their nasopharyngeal viral reverse-transcription polymerase chain reaction (RT-PCR) burden, and their antibody levels over time, revealing the infection dynamics by RT-PCR and serology during the acute phase. Notably, a novel serological test for antibodies against the receptor binding domain of SARS-CoV-2 showed that 100% of our asymptomatic cohort remained seropositive 3—6 weeks after diagnosis.