Flow resistance and drag forces due to multiple adherent leukocytes in postcapillary vessels
Flow resistance and drag forces due to multiple adherent leukocytes in postcapillary vessels
复制标题
DOI：
10.1016/s0006-3495(98)78036-1
复制
发表时间：
1998-06-01
影响因子：
3.4
通讯作者：
Cokelet, GR
中科院分区：
文献类型：
--
作者：
Chapman, GB;Cokelet, GR
计算流体动力学用于模拟在毛细血管后大小的血管中通过多个粘附白细胞的流动。采用有限元方法求解了低雷诺数牛顿流体通过附着在圆柱形容器壁上的球体时的Navier-Stokes方程。我们确定了球体数、相对几何形状和间距对容器内流动阻力和流体流动阻力的影响，这些阻力作用于将球体从容器壁上扫走。计算表明，当粘附的白细胞排列在血管的同一侧时，每个相互作用的白细胞所受的阻力小于孤立的粘附白细胞所受的阻力，并且可以减少高达50%。减少的幅度取决于白细胞与血管直径的比例和粘附白细胞之间的距离。然而，当白细胞粘附在血管壁的两侧时，阻力会增加。根据计算结果计算了不同大小的血管中粘附的白细胞所产生的阻力的增加。阻力随血管大小的减小而增大，当白细胞粘附在血管的两侧时阻力最明显。
Computational fluid dynamics was used to model flow past multiple adherent leukocytes in postcapillary size vessels. A finite-element package was used to solve the Navier-Stokes equations for low Reynolds number flow of a Newtonian fluid past spheres adhering to the wall of a cylindrical vessel. We determined the effects of sphere number, relative geometry, and spacing on the flow resistance in the vessel and the fluid flow drag force acting to sweep the sphere off the vessel wall. The computations show that when adherent leukocytes are aligned on the same side of the vessel, the drag force on each of the interacting leukocytes is less than the drag force on an isolated adherent leukocyte and can decrease by up to 50%. The magnitude of the reduction depends on the ratio of leukocyte to blood vessel diameter and distance between adherent leukocytes. However, there is an increase in the drag force when leukocytes adhere to opposite sides of the vessel wall. The increase in resistance generated by adherent leukocytes in vessels of various sizes is calculated from the computational results. The resistance increases with decreasing vessel size and is most pronounced when leukocytes adhere to opposite sides of the vessel.