Enriched environment restores impaired hippocampal long-term potentiation and water maze performance induced by developmental lead exposure in rats
Enriched environment restores impaired hippocampal long-term potentiation and water maze performance induced by developmental lead exposure in rats
复制标题
丰富的环境可恢复因发育性铅暴露引起的大鼠海马长时程增强和水迷宫性能受损
DOI：
10.1002/dev.20287
复制
发表时间：
2008-04-01
影响因子：
2.2
通讯作者：
Ruan, Diyun
中科院分区：
文献类型：
--
作者：
Cao, Xiujing;Huang, Shenghai;Ruan, Diyun
儿童接触铅(Pb2+)会导致长期的认知功能障碍，并已在实验动物中建立了模型。已有研究表明，如果给动物提供丰富的环境，发育期铅暴露所致的学习障碍是可逆的，在此，我们询问环境丰富(EE)是否也能逆转铅引起的长期电位(LTP)损害。大鼠在整个妊娠和哺乳期饮用1500 ppm的醋酸铅(PBAC)溶液或蒸馏水。在出生后第22天断奶后，对照组和铅暴露组雄性后代的一半通过所有实验进行环境富集化处理，直到测试。8周龄时进行电生理和Morris水迷宫试验。结果表明，EE可逆转铅所致的学习能力减退。此外，我们的结果还表明，铅对EPSP LTP和PS LTP的损伤也是EE经验可逆的。(C)2008年威利期刊公司。
Lead (Pb2+) exposure in children can induce long lasting deficits in cognitive function and has been modeled in experimental animals. Based on previous studies which demonstrated that learning impairments resulting from developmental Pb2+ exposure were reversible if the animals were provided with all enriched environment, here, we asked if environmental enrichment (EE) could also reverse long-term potention (LTP) impairment induced by lead. Rats drank 1,500 ppm lead acetate (PbAc) solution or distilled water throughout gestation and lactation. After weaning at postnatal Day 22, one half of the control and lead-exposed male offspring were given the environmental enrichment treatment through all the experiments until tested. Electrophysiological and Morris water maze test were performed at 8 weeks of age. The result showed that the impaired learning ability induced by lead could be reversed by EE. Furthermore, our results revealed that EPSP LTP and PS LTP impairments induced by lead were also reversible by EE experience. (C) 2008 Wiley Periodicals, Inc.