THE EARLY CHANGES IN SALIVARY-GLAND FUNCTION DURING AND AFTER RADIOTHERAPY GIVEN FOR HEAD AND NECK-CANCER
THE EARLY CHANGES IN SALIVARY-GLAND FUNCTION DURING AND AFTER RADIOTHERAPY GIVEN FOR HEAD AND NECK-CANCER
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DOI：
10.1016/0167-8140(94)90006-x
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发表时间：
1994-01-01
影响因子：
5.7
通讯作者：
DISCHE, S
中科院分区：
文献类型：
--
作者：
LESLIE, MD;DISCHE, S
对 47 名接受根治性放射治疗（CHART 或传统分割治疗）的头颈癌患者的唾液腺功能进行了研究，包括治疗前、治疗期间以及治疗开始后长达 12 周的时间。一旦放疗开始，特别是当两个腮腺都包含在治疗范围内时，唾液流量和 pH 值就会明显下降。流量减少的初始速率反映了治疗的实施速率。与其他唾液腺相比，腮腺对放射治疗最敏感，唾液流量的减少取决于剂量和治疗体积中腺体的比例。对于接受 CHART 或传统分次治疗的患者来说，唾液腺功能的这些早期变化非常明显，因此与 CHART 后显示不太明显的晚期变化不同。
The salivary gland function of 47 patients treated by radical radiotherapy (CHART or conventionally fractionated treatment) for head and neck cancer has been studied before, during and for up to 12 weeks from the start of treatment. Pronounced falls in salivary flow and pH are seen once radiotherapy has commenced, particuarly when both parotid glands are included in the treatment volume. The initial rate of reduction in flow reflects the rate of delivery of treatment. The parotid glands show the greatest sensitivity to radiotherapy compared with the other salivary glands and reduction in salivary flow is dependent on both dose and the proportion of the gland included in the treatment volume. These early changes in salivary gland function are as marked for patients receiving either CHART or conventionally fractionated treatment, so differing from the late changes which have been shown to be less evident after CHART.