Cadmium Exposure Is Associated With Elevated Blood C-Reactive Protein and Fibrinogen in the U. S. Population: The Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994)
Cadmium Exposure Is Associated With Elevated Blood C-Reactive Protein and Fibrinogen in the U. S. Population: The Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994)
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DOI：
10.1016/j.annepidem.2009.02.005
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发表时间：
2009-08-01
影响因子：
5.6
通讯作者：
Caffrey, James J.
中科院分区：
文献类型：
--
作者：
Lin, Yu-Sheng;Rathod, Dhruv;Caffrey, James J.
目得：流行病学数据表明镉暴露与心血管疾病之间存在关联，但其潜在机制尚不清楚。本研究探讨了镉暴露与C-反应蛋白（CRP）和纤维蛋白原升高相关的假设，这两个因素是心血管疾病的两个危险因素。目前的研究调查了尿镉与血CRP升高患病率之间的关系（>= 2.2 mg/L）和纤维蛋白原（>= 10.35 μ mol/L）。Logistic回归模型被用来调查现有的协会，同时调整混杂variables.RESULTS：简单和协变量调整模型均表明，尿镉与CRP和纤维蛋白原升高呈剂量依赖性（P（趋势）< 0.05）。与尿镉的最高和最低四分位数相比，CRP和纤维蛋白原升高的校正比值比分别为1.62（95%置信区间[CI]，1.24-2.12）和2.12（1.43-3.14）。需要进行进一步的研究，以确定增加的风险是来自镉本身，还是来自造成污染的环境条件，例如，吸烟。Ann Epidemiol 2009;19：592-596.爱思唯尔公司出版
PURPOSE: Epidemiologic data suggest an association between cadmium exposure and cardiovascular disease though the underlying mechanisms remain unclear. This study explored the hypothesis that cadmium exposure is associated with elevated C-reactive protein (CRP) and fibrinogen, two risk factors for developing cardiovascular disease.METHODS: The current study investigated associations between urinary cadmium and the prevalence of elevated blood CRP (>= 2.2 mg/L) and fibrinogen (>= 10.35 mu mol/L) using data from a sample of 6497 participants aged 40-79 in the Third National Health and Nutrition Examination Survey. Logistic regression model was used to investigate existing associations while adjusting for confounding variables.RESULTS: Both simple and covariate-adjusted models indicated that urinary cadmium was associated with elevated CRP and fibrinogen in a dose-dependent fashion (p(trend) < 0.05 for both). Adjusted odds ratios for increased CRP and fibrinogen comparing highest with lowest quartiles of urinary cadmium were 1.62 (95% confidence interval [CI], 1.24-2.12) and 2.12 (1.43-3.14), respectively.CONCLUSIONS: This analysis shows that cadmium exposure is associated with high prevalence of elevated CRP and fibrinogen. Additional study will be required to determine whether the increased risk derives from cadmium per se or from the environmental circumstances responsible for acquiring the contamination, e.g., cigarette smoking. Ann Epidemiol 2009;19:592-596. Published by Elsevier Inc.