Squamous cell carcinoma antigen, circulating immune complexes, and immunoglobulins in monitoring squamous cell carcinoma of head and neck - A study of the Hellenic Co-Operative Oncology Group (HeCOG)
Squamous cell carcinoma antigen, circulating immune complexes, and immunoglobulins in monitoring squamous cell carcinoma of head and neck - A study of the Hellenic Co-Operative Oncology Group (HeCOG)
复制标题
DOI：
10.1097/00000421-199912000-00002
复制
发表时间：
1999-12-01
影响因子：
2.6
通讯作者：
Fountzilas, G
中科院分区：
文献类型：
--
作者：
Makrantonakis, P;Pectasides, D;Fountzilas, G
本研究探讨了鳞状细胞癌抗原（SCC-Ag）、循环免疫复合物（CIC）和免疫球蛋白（伊加、IgG、IgM）在117例接受局部和/或全身治疗的头颈部鳞状细胞癌（SCC-HN）患者的诊断、监测和预后中的临床应用。在一项前瞻性研究中测量了血清标志物水平。SCC-Ag阳性率为28.2%，CIC阳性率为63.2%，伊加阳性率为11.1%，IgG阳性率为15.4%，IgM阳性率为9.44%。统计学显著相关性之间的初始SCC-Ag水平和肿瘤定位，而CIC水平显着增加与疾病的进展阶段。研究还发现，治疗结束时SCC-Ag、伊加和CIC水平的显著降低与无病状态的发生率增加相关。IgG的初始值和疾病分期与良好的治疗结果显著相关。治疗前升高的SCC-Ag和IgM血清值显示出预测疾病进展的显著趋势。使用考克斯比例风险模型，IgG血清值、原发部位和疾病分期是至进展时间的显著预测因素。治疗完成时SCC-Ag、伊加和CIC值的显著降低与无病状态发生率的增加相关。这项研究表明，只有SCC-Ag的估计，并在一定程度上的IgM和/或IgG是一个潜在的工具，监测治疗的疗效或疾病复发的SCC-HN。
This study investigates the clinical utility of squamous cell carcinoma antigen (SCC-Ag), circulating immune complexes (CIC), and immunoglobulins (IgA, IgG, IgM) in the diagnosis, monitoring, and prognosis of 117 squamous cell carcinoma of the head and neck (SCC-HN) patients having local and/or systemic treatment. Serum marker levels were measured in a prospective study. SCC-Ag was positive in 28.2% of patients, the CIC in 63.2%, the IgA in 11.1%, the IgG in 15.4%, and the IgM in 9.44%. Statistically significant correlation was found between the initial SCC-Ag levels and tumor localization, whereas the CIC levels were increasing significantly with progressing disease stages. It was also found that the significant decrease of SCC-Ag, IgA, and CIC levels at the end of treatment was correlated with an increased incidence of disease-free status. The initial values of IgG and the disease stage were significantly correlated with a favorable treatment outcome. The pretreatment elevated SCC-Ag and IgM serum values showed a significant trend to predict a disease progression. Using a Cox proportional hazards model the IgG serum values, the primary site, and the disease stage were significant predictors for time to progression The significant decrease of SCC-Ag, IgA, and CIC values at the completion of treatment was correlated with an increased incidence of disease-free status. This study indicates that only the estimation of SCC-Ag and in some degree the IgM and/or IgG is a potential tool for monitoring the efficacy of treatment or disease recurrence in SCC-HN.