The PennBMBI: Design of a General Purpose Wireless Brain-Machine-Brain Interface System
The PennBMBI: Design of a General Purpose Wireless Brain-Machine-Brain Interface System
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DOI：
10.1109/tbcas.2015.2392555
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发表时间：
2015-04-01
影响因子：
5.1
通讯作者：
Van der Spiegel, Jan
中科院分区：
文献类型：
--
作者：
Liu, Xilin;Zhang, Milin;Van der Spiegel, Jan
本文介绍了一种通用的无线脑-机-脑接口系统。该系统集成了四个电池供电的无线设备，以实现闭环感觉运动神经接口，包括神经信号分析仪、神经刺激器、身体区域传感器节点和在PC端实现的图形用户界面。神经信号分析仪具有四通道模拟前端，具有可配置的带通滤波器、增益级、数字化分辨率和采样率。目标频段可配置为从EEG到单个单位活动。在0.05赫兹到6千赫的带宽上，噪声下限为4.69微伏毫秒。数字滤波、神经特征提取、棘波检测、感知刺激调制和压缩感知测量由集成在分析仪中的中央处理单元实现。分析仪中还集成了闪存卡。包括一个双通道神经刺激器，其顺应性电压高达+/-12V。该刺激器能够提供具有可编程脉冲形状、幅度、宽度、脉冲串频率和潜伏期的单极或双极电荷平衡电流脉冲。设计了一种多功能传感器节点，包括加速度计、温度传感器、挠性力传感器和通用传感器扩展接口。根据定制的通信协议，计算机接口被设计成通过无线链路来监视、控制和配置所有上述设备。可以配置感官设备、神经刺激器和神经信号分析仪之间的无线闭环操作。拟议的系统旨在连接大脑中的两个位置，连接大脑和外部硬件，并为临床实践创建新的感觉和运动路径。进行了台架试验和体内实验，验证了系统的功能和性能。
In this paper, a general purpose wireless Brain-Machine-Brain Interface (BMBI) system is presented. The system integrates four battery-powered wireless devices for the implementation of a closed-loop sensorimotor neural interface, including a neural signal analyzer, a neural stimulator, a body-area sensor node and a graphic user interface implemented on the PC end. The neural signal analyzer features a four channel analog front-end with configurable bandpass filter, gain stage, digitization resolution, and sampling rate. The target frequency band is configurable from EEG to single unit activity. A noise floor of 4.69 mu Vrms is achieved over a bandwidth from 0.05 Hz to 6 kHz. Digital filtering, neural feature extraction, spike detection, sensing-stimulating modulation, and compressed sensing measurement are realized in a central processing unit integrated in the analyzer. A flash memory card is also integrated in the analyzer. A 2-channel neural stimulator with a compliance voltage up to +/- 12 V is included. The stimulator is capable of delivering unipolar or bipolar, charge-balanced current pulses with programmable pulse shape, amplitude, width, pulse train frequency and latency. A multi-functional sensor node, including an accelerometer, a temperature sensor, a flexiforce sensor and a general sensor extension port has been designed. A computer interface is designed to monitor, control and configure all aforementioned devices via a wireless link, according to a custom designed communication protocol. Wireless closed-loop operation between the sensory devices, neural stimulator, and neural signal analyzer can be configured. The proposed system was designed to link two sites in the brain, bridging the brain and external hardware, as well as creating new sensory and motor pathways for clinical practice. Bench test and in vivo experiments are performed to verify the functions and performances of the system.