Long noncoding RNA FER1L4 acts as an oncogenic driver in human pan-cancer
Long noncoding RNA FER1L4 acts as an oncogenic driver in human pan-cancer
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长非编码 RNA FER1L4 在人类泛癌中充当致癌驱动因素
DOI：
10.1002/jcp.29098
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发表时间：
2020
影响因子：
5.6
通讯作者：
Xu Shouping
中科院分区：
文献类型：
--
作者：
You Zilong;Ge Anqi;Pang Da;Zhao Yashuang;Xu Shouping
The function of Fer‐1 like family member 4 (FER1L4) in human pan‐cancer is unknown. Expression ofFER1L4in tumor tissues and nontumor tissues, upstream regulation ofFER1L4, and the relationship between its expression with prognosis and chemoresistance were examined by The Cancer Genome Atlas and Gene Expression Omnibus databases. Next, these results were validated in breast tumor and paired nontumor tissues in our cohort.FER1L4expression is higher in tumor tissues compared with the adjacent nontumor tissues. HighFER1L4expression is associated with worse disease outcomes. Hypomethylation and H3K4me3 accumulation inFER1L4promoter locus activate its transcriptional expression. Moreover,FER1L4may trigger chemoresistance in human cancer. Gene Ontology enrichment analysis revealed thatFER1L4may be involved in processes associated with tumorigenesis. These results indicated thatFER1L4may act as an oncogenic driver and it may be a potential therapy target in human cancer.
