Cortical thickness and VBM-DARTEL in late-life depression
Cortical thickness and VBM-DARTEL in late-life depression
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DOI：
10.1016/j.jad.2011.04.010
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发表时间：
2011-09-01
影响因子：
6.6
通讯作者：
O'Brien, John T.
中科院分区：
文献类型：
--
作者：
Colloby, Sean J.;Firbank, Michael J.;O'Brien, John T.
背景：大量研究揭示了晚年抑郁症的大脑结构变化，主要是白质或整个脑叶，很少集中在灰质（GM）。目的是使用两种不同的方法，即额叶结构的皮质厚度和基于体素的形态测量 (VBM)，研究老年抑郁症和类似年龄的健康受试者的 GM 变化。方法：68 名受试者参与（30 名健康对照受试者，38 名抑郁症受试者）并接受 3T T1 MR 成像以及临床和认知评估。使用 FreeSurfer 测量额叶皮质厚度，同时使用 SPM8 中的 DARTEL 算法进行 VBM。使用ANCOVA 评估皮质厚度和GM 体积的组间差异。还研究了皮质厚度和 VBM 结果对认知和抑郁变量的影响。结果：各组之间额叶皮质厚度没有观察到显着差异 (F(1, 62) = 0.1）。此外，未发现皮质厚度与认知和抑郁评分之间存在显着关系（偏相关竖条 r'竖条 = 0.01-0.31，p >= 0.06）。 VBM 显示各组之间的 GM 体积无法区分，但与诊断无关，显着的年龄影响是明显的。结论：结果表明晚年抑郁症 (LLD) 的皮质 GM 变化与健康的老年受试者相似，并且似乎与年龄有关，而不是与认知或抑郁症状有关。白质和皮层下 GM 结构的变化可能更能解释 LLD 的神经生物学基础。 (C) 2011 Elsevier B.V. 保留所有权利。
Background: Numerous studies have revealed structural brain changes in late life depression, mainly in white matter or whole lobes with few focussing just on grey matter (GM). The objective was to investigate GM changes in older depressed and similar aged healthy subjects using two different methods, cortical thickness in frontal lobe structures and voxel-based morphometry (VBM).Methods: Sixty eight subjects participated (30 healthy comparison subjects, 38 depressed) and underwent 3T T1 MR imaging as well as clinical and cognitive assessments. Frontal cortical thickness was measured using FreeSurfer while VBM was undertaken using the DARTEL algorithm in SPM8. Group differences in cortical thickness and GM volumes were assessed using ANCOVA. Effects of cortical thickness and VBM results on cognitive and depression variables were also investigated.Results: No significant differences in frontal lobe cortical thickness were observed between groups (F(1, 62) = 0.1). In addition, no significant relationships of cortical thickness on cognitive and depression scores were identified (partial correlation vertical bar r'vertical bar = 0.01-0.31, p >= 0.06). VBM showed that GM volumes were indistinguishable between groups but significant age effects were apparent, independent of diagnosis.Conclusions: Results suggest that cortical GM changes in late life depression (LLD) are similar to healthy older subjects and appear to be related to age rather than cognitive or depressive symptoms. Changes to white matter and subcortical GM structures may be more relevant in explaining the underlying neurobiology of LLD. (C) 2011 Elsevier B.V. All rights reserved.