Selective control of working memory in prefrontal, parietal, and visual cortex
Selective control of working memory in prefrontal, parietal, and visual cortex
复制标题
前额叶、顶叶和视觉皮层工作记忆的选择性控制
DOI：
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复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
T. J. Buschman
中科院分区：
文献类型：
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作者：
Matthew F. Panichello;T. J. Buschman
认知控制通过控制信息在大脑中呈现的内容、位置和方式来指导行为。以前的研究已经表明，顶叶和前额叶皮质直接注意，它控制外部感觉刺激的表征1，2。然而，在工作记忆中，控制脑海中表征选择的神经机制尚不清楚。为了解决这个问题，我们训练了两只猴子在两个任务之间切换，要求它们要么从工作记忆中保存的一组项目中选择一个项目，要么关注一组视觉刺激中的一个刺激。前额叶、顶叶和视觉皮质的同时神经记录发现，前额叶皮质在从工作记忆中选择项目方面发挥了主要作用，代表了先于顶叶和视觉皮质的选择。令人惊讶的是，前额叶皮质的一个共同的群体表征编码了工作记忆中对项目的选择和对外部刺激的关注，这表明前额叶皮质可能扮演着领域通用控制器的角色。选择以两种方式影响记忆表征。首先，选择通过增强所选项目在前额叶和顶叶皮质的表现，提高了记忆报告的准确性。第二，选择以任务相关的方式转换记忆表征。在选择之前，当两个项目都与任务相关时，每个项目的身份被表示在神经活动的一个独立子空间中。在选择之后，只有所选项目的表示被转换到一个新的子空间，用于指导动物的行为报告。总之，我们的结果为前额叶皮质如何控制工作记忆表征提供了洞察力，有选择地增强和转换它们以支持行为。
Cognitive control guides behavior by controlling what, where, and how information is represented in the brain. Previous work has shown parietal and prefrontal cortex direct attention, which controls the representation of external sensory stimuli1,2. However, the neural mechanisms controlling the selection of representations held ‘in mind’, in working memory, are unknown. To address this, we trained two monkeys to switch between two tasks, requiring them to either select an item from a set of items held in working memory or attend to one stimulus from a set of visual stimuli. Simultaneous neural recordings in prefrontal, parietal, and visual cortex found prefrontal cortex played a primary role in selecting an item from working memory, representing selection before parietal and visual cortex. Surprisingly, a common population representation in prefrontal cortex encoded selection of an item in working memory and attention to an external stimulus, suggesting prefrontal cortex may act as a domain-general controller. Selection acted on memory representations in two ways. First, selection improved the accuracy of memory reports by enhancing the selected item’s representation in prefrontal and parietal cortex. Second, selection transformed memory representations in a task-dependent manner. Before selection, when both items were relevant to the task, the identity of each item was represented in an independent subspace of neural activity. After selection, the representation of only the selected item was transformed into a new subspace that was used to guide the animal’s behavioral report. Together, our results provide insight into how prefrontal cortex controls working memory representations, selectively enhancing and transforming them to support behavior.
DOI：
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发表时间：
2014
期刊：
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影响因子：
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作者：
Matthew T. Kaufman;M. Churchland;S. Ryu
通讯作者：
Matthew T. Kaufman;M. Churchland;S. Ryu
影响因子：
2.5
作者：
Tort, Adriano B. L.;Komorowski, Robert;Kopell, Nancy
通讯作者：
Kopell, Nancy