Effect of atrial fibrillation on long‐term survival in patients hospitalised for heart failure with preserved ejection fraction ☆
Effect of atrial fibrillation on long‐term survival in patients hospitalised for heart failure with preserved ejection fraction ☆
复制标题
房颤对射血分数保留的心力衰竭住院患者长期生存的影响☆
DOI：
10.1016/j.ejheart.2008.04.002
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发表时间：
2008
影响因子：
18.2
通讯作者：
C. Tribouilloy
中科院分区：
文献类型：
--
作者：
D. Ruşinaru;L. Leborgne;M. Peltier;C. Tribouilloy
背景心房颤动（AF）对心力衰竭（HF）预后的重要性尚未明确。在收缩期HF中进行的研究导致了不一致的结果。AimsTo evaluate the relationship between AF and long-term survival in patients with heart failure and preserved ejection fraction（HFPEF）.Methods and resultsWe prospectively included 368 continuous patients住院治疗的HFPEF首次发作在2000年和比较5年的结果根据AF的存在或不存在的患者在基线心电图。倾向评分用于减少基线特征的不平衡。在36%（n=132）的研究人群中观察到基线AF。AF患者年龄较大，更常患有高血压性心脏病。在单变量分析中，基线AF与5年总死亡率风险增加相关（HR=1.36; 95%CI 1.03-1.79;p=0.03）。校正协变量后，基线AF不再是生存率降低的预测因子。有和无AF患者的校正心血管死亡风险相当。在倾向匹配的患者中，AF与不良结局无关（HR=1.08; 95%CI 0.78-1.51;p=0.63）。结论在因HFPEF住院的患者中，AF频繁发生，并与主要与这些患者高龄相关的死亡率过高相关。校正协变量后，基线AF不是长期死亡率的独立预测因素。
BackgroundThe prognostic importance of atrial fibrillation (AF) in heart failure (HF) is not clearly established. Studies conducted in systolic HF have led to discordant results.AimsTo evaluate the relation between AF and long‐term survival in patients with heart failure and preserved ejection fraction (HFPEF).Methods and resultsWe prospectively included 368 consecutive patients hospitalised for a first episode of HFPEF during 2000 and compared the 5‐year outcome of patients according to the presence or absence of AF on the baseline electrocardiogram. Propensity scores were used to reduce imbalance in baseline characteristics. Baseline AF was observed in 36% (n=132) of the study population. Patients with AF were older and more often had hypertensive heart disease. On univariate analysis, baseline AF was associated with an increased risk of 5‐year overall mortality (HR=1.36; 95%CI 1.03–1.79;p=0.03). After adjustment for covariates, baseline AF was no longer a predictor of reduced survival. The risk of adjusted cardiovascular death in patients with and without AF was comparable. In the propensity‐matched patients, AF was not related to a poorer outcome (HR=1.08; 95%CI 0.78–1.51;p=0.63).ConclusionIn patients hospitalised for HFPEF, AF is frequent and associated with an excess mortality mainly related to the advanced age of these patients. After adjustment for covariates, baseline AF is not an independent predictor of long‐term mortality.
影响因子：
37.8
作者：
Senni, M;Tribouilloy, CM;Redfield, MM
通讯作者：
Redfield, MM
影响因子：
5
作者：
M. Joffe;P. Rosenbaum
通讯作者：
M. Joffe;P. Rosenbaum
影响因子：
158.5
作者：
Owan, Theophilus E.;Hodge, David O.;Redfield, Margaret M.
通讯作者：
Redfield, Margaret M.