Prostaglandin E2 in temporomandibular joint synovial fluid and its relation to pain and inflammatory disorders
Prostaglandin E2 in temporomandibular joint synovial fluid and its relation to pain and inflammatory disorders
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DOI：
10.1016/s0278-2391(00)90335-5
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发表时间：
2000-02-01
影响因子：
1.9
通讯作者：
Kopp, S
中科院分区：
文献类型：
--
作者：
Alstergren, P;Kopp, S
目的：本研究的目的是探讨颞下颌关节（TMJ）滑液（SF）的前列腺素E-2的水平和一般的炎症活动的关系，其对特定的TMJ疼痛的患者与炎症性TMJ disorders.Patients和方法：本研究包括24例（30关节）与炎症性TMJ疾病和4名健康人（6关节）。评估了休息时的TMJ疼痛、TMJ触诊压痛、TMJ压痛阈值以及关节运动时的疼痛（PM）。结果：健康人TMT SF中PGE（2）在血浆中未检出，而在正常人TMT SF中PGE（2）在血浆中未检出。在30例患者的SF样本中，20例（67%）可检测到PGE（2）。SF-PGE（2）：Ind与PM呈正相关。P-PGE（2）与B-ESR和S-CRP之间存在显著相关性。结论：本研究表明TMJ炎性疾病患者滑液中经常存在可检测到的PGE（2）水平，其与TMJ异常性疼痛相关。血浆PGE（2）水平似乎与这些患者的全身炎症活动有关。
Purpose: The aim of this study was to investigate temporomandibular joint (TMJ) synovial fluid (SF) levels of prostaglandin E-2 and its relation to general inflammatory activity and its influence on specific TMJ pain in patients with inflammatory TMJ disorders.Patients and Methods: The study comprised 24 patients (30 joints) with inflammatory TMJ disorders and 4 healthy persons (6 joints). TMJ pain at rest, tenderness to palpation of the TMJ, and TMJ pressure pain threshold, as well as pain during joint movements (PM), were assessed. PGE levels were analyzed in synovial fluid samples (SF-PGE(2)) and blood plasma (P-PGE(2)), The erythrocyte sedimentation rate (B-ESR) as well as the serum levels of C-reactive protein (S-CRP) and antinuclear antibodies were determined.Results: PGE(2) was undetectable in the plasma find in the TMT SF of the healthy persons. In the patients, PGE(2) was detectable in 20 of the 30 (67%) SF samples. SF-PGE(2) was significantly :Ind positively correlated to PM in the patients. There were significant correlations between P-PGE(2) and B-ESR as well as the S-CRP,Conclusions: This study shows that the synovial fluid in patients with TMJ inflammatory disorders frequently has a detectable level of PGE(2) that is related to TMJ allodynia. The plasma levels of PGE(2) seem to be related to the general inflammatory activity in these patients.