Brain rhythm attractor breakdown in Alzheimer's disease: Functional and pathologic implications.
Brain rhythm attractor breakdown in Alzheimer's disease: Functional and pathologic implications.
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DOI：
10.1016/j.jalz.2017.02.003
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Vossel KA
中科院分区：
文献类型：
--
作者：
Karageorgiou E;Vossel KA
This perspective binds emerging evidence on the bidirectional relationship between Alzheimer’s disease (AD) and sleep disorders through a model of brain rhythm attractor breakdown. This approach explains behavioral-cognitive changes in AD across the sleep-wake cycle and supports a causal association between early brainstem tau pathology and subsequent cortical amyloid-β accumulation. Specifically, early tau dysregulation within brainstem-hypothalamic nuclei leads to breakdown of sleep-wake attractor networks, with patients displaying an attenuated range of behavioral and electrophysiological activity patterns, a “twilight zone” of constant activity between deep rest and full alertness. This constant cortical activity promotes activity-dependent amyloid-β accumulation in brain areas that modulate their activity across sleep-wake states, especially the medial prefrontal cortex (mPFC). Additionally, the accompanying breakdown of hippocampal-mPFC interplay across sleep stages could explain deficient memory consolidation through dysregulation of synaptic plasticity. Clinical implications include the potential therapeutic benefit of attractor consolidation (e.g., slow-wave sleep enhancers) in delaying AD progression.
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