Increased TGF-beta1 protein expression in patients with advanced colorectal cancer
Increased TGF-beta1 protein expression in patients with advanced colorectal cancer
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DOI：
10.1002/jso.20961
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发表时间：
2008-04-01
影响因子：
2.5
通讯作者：
Ivarsson, Marie-Louise
中科院分区：
文献类型：
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作者：
Langenskiod, Marcus;Holmdahl, Lena;Ivarsson, Marie-Louise
有证据表明tgf - β 1在早期疾病中发挥抑瘤作用，在肿瘤晚期具有促癌作用。该研究的目的是将血浆和组织中的tgf - β 1与不同疾病进展阶段患者的临床和病理参数联系起来。方法：对169例结直肠癌手术患者进行前瞻性研究。血液、无瘤粘膜及肿瘤活检检查。结果：肿瘤中tgf - β 1蛋白表达随t期延长而升高，无论是否纳入转移性疾病患者（P = 0.0006）。与没有转移性疾病的患者相比，转移性疾病患者在肿瘤组织（P = 0.004）和血浆（P = 0.001）中tgf - β 1蛋白表达均升高。无论是否包括转移性疾病患者，肿瘤组织和无肿瘤肠道中，结肠中tgf - β 1蛋白的表达均高于直肠（P = 0.03）。这种差异主要是由于淋巴结阳性的非转移患者中tgf - β 1蛋白表达较高（P = 0.005）。结论：较高的tgf - β 1蛋白表达与t期和转移性疾病增加相关，表明tgf - β 1在肿瘤进展中起重要作用。肿瘤的定位似乎影响肿瘤细胞阳性淋巴结患者的tgf - β 1蛋白表达。
Introduction: There is evidence that TGF-beta 1 plays a role as a tumor suppressor in early disease and has pro-oncogenic effects in advanced tumor stage. The aim of the study was to correlate TGF-beta 1 in plasma and tissue to clinical and pathological parameters in patients with various stages of disease progression.Methods: One hundred sixty-nine patients who underwent surgery for a colorectal carcinoma were prospectively included. Blood samples, tumor free mucosa and tumor biopsies were assayed.Results: TGF-beta 1 protein expression in tumors increased with increasing T-stage regardless of whether patients with metastatic disease were included or not (P = 0.0006). Patients with metastatic disease showed elevated TGF-beta 1 protein expression in both tumor tissue (P = 0.004) and plasma (P = 0.001) compared to those without metastatic disease. TGF-beta 1 protein expression was higher in the colon compared with the rectum in both tumor tissue and tumor-free bowel (P = 0.03), regardless of whether patients with metastatic disease were included or not. This difference was mainly attributable to a higher TGF-beta 1 protein expression in non-metastatic patients with lymph node positivity (P = 0.005).Conclusions: Higher TGF-beta 1 protein expression is associated with increasing T-stage and metastatic disease, indicating that TGF-beta 1 is of importance in tumor progression. The localization of the tumor seems to influence the TGF-beta 1 protein expression in patients with tumor cell-positive lymph nodes.