A meta-analysis of case-control studies of the association of migraine and patent foramen ovale
A meta-analysis of case-control studies of the association of migraine and patent foramen ovale
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DOI：
10.1016/j.jjcc.2015.09.016
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发表时间：
2016-05-01
影响因子：
2.5
通讯作者：
Umemoto, Takuya
中科院分区：
文献类型：
--
作者：
Takagi, Hisato;Umemoto, Takuya
目的：为了建立定量证据，我们对评估偏头痛与卵圆孔未闭（PFO）之间关系的病例对照研究进行了首次荟萃分析。方法：使用PubMed和奥维德检索MEDLINE和EMBASE，检索时间截止2015年4月。符合条件的研究是病例对照研究报告PFO（或偏头痛）患病率偏头痛患者与无偏头痛科目（或PFO患者与无PFO科目）。结果：395个潜在的相关文章初步筛选，21个合格的研究，共招募5572名参与者被确定和列入。合并分析显示，有先兆偏头痛患病率为3.36倍[比值比（OR），3.36; 95%置信区间（CI），2.04-5.55; p < 0.00001]，有/无先兆偏头痛患病率为2.46倍，具有统计学意义（OR，2.46; 95% CI，1.55-3.91; p = 0.0001）但无统计学意义的1.30倍无先兆偏头痛患病率（OR，1.30; 95%CI，0.85-1.99; p = 0.22）。PFO与3.4倍有先兆偏头痛和2.5倍有/无先兆偏头痛患病率相关，但与无先兆偏头痛患病率无关。(C)2015年由Elsevier Ltd代表日本心脏病学院发表。
Objectives: To establish quantitative evidence, we performed the first meta-analysis of case-control studies assessing the relationship between migraine and patent foramen ovale (PFO).Methods: MEDLINE and EMBASE were searched through April 2015 using PubMed and OVID. Eligible studies were case-control studies reporting PFO (or migraine) prevalence in migraine patients versus no migraine subjects (or PFO patients versus no-PFO subjects).Results: Of 395 potentially relevant articles screened initially, 21 eligible studies enrolling a total of 5572 participants were identified and included. Pooled analyses demonstrated statistically significant 3.36-fold migraine-with-aura [odds ratio (OR), 3.36; 95% confidence interval (CI), 2.04-5.55; p < 0.00001] and 2.46-fold migraine-with/without-aura prevalence (OR, 2.46; 95% CI, 1.55-3.91; p = 0.0001) but statistically non-significant 1.30-fold migraine-without-aura prevalence (OR, 1.30; 95% CI, 0.85-1.99; p = 0.22) in PFO patients relative to no-PFO subjects.Conclusions: PFO is associated with 3.4-fold migraine-with-aura and 2.5-fold migraine-with/without-aura prevalence but unassociated with migraine-without-aura prevalence. (C) 2015 Published by Elsevier Ltd on behalf of Japanese College of Cardiology.