Microglia: A Potential Therapeutic Target for Sepsis-Associated Encephalopathy and Sepsis-Associated Chronic Pain.
Microglia: A Potential Therapeutic Target for Sepsis-Associated Encephalopathy and Sepsis-Associated Chronic Pain.
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小胶质细胞：脓毒症相关脑病和脓毒症相关慢性疼痛的潜在治疗靶点
DOI：
10.3389/fphar.2020.600421
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发表时间：
2020
影响因子：
5.6
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Li Y;Yin L;Fan Z;Su B;Chen Y;Ma Y;Zhong Y;Hou W;Fang Z;Zhang X
神经功能障碍是脓毒症患者的严重表现之一，与重症监护室中死亡率和长期并发症（包括脓毒症相关脑病（SAE）和慢性疼痛）的增加密切相关。这些脓毒症引起的神经功能障碍的潜在机制是难以捉摸的。然而，已经充分确定，小胶质细胞，在中枢神经系统中占主导地位的常驻免疫细胞，在SAE和慢性疼痛的发生和发展中发挥重要作用。脓毒症急性期小胶质细胞可被炎性介质、邻近细胞和神经递质激活，导致脑内神经元功能障碍。随着小胶质细胞与脓毒症之间关系的关注，可以更深入地了解SAE和慢性疼痛中的小胶质细胞。更重要的是，阐明小胶质细胞中脓毒症相关信号通路的机制将为SAE和慢性疼痛的治疗策略提供新的思路。
Neurological dysfunction, one of the severe manifestations of sepsis in patients, is closely related to increased mortality and long-term complications in intensive care units, including sepsis-associated encephalopathy (SAE) and chronic pain. The underlying mechanisms of these sepsis-induced neurological dysfunctions are elusive. However, it has been well established that microglia, the dominant resident immune cell in the central nervous system, play essential roles in the initiation and development of SAE and chronic pain. Microglia can be activated by inflammatory mediators, adjacent cells and neurotransmitters in the acute phase of sepsis and then induce neuronal dysfunction in the brain. With the spotlight focused on the relationship between microglia and sepsis, a deeper understanding of microglia in SAE and chronic pain can be achieved. More importantly, clarifying the mechanisms of sepsis-associated signaling pathways in microglia would shed new light on treatment strategies for SAE and chronic pain.
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影响因子：
4.6
作者：
Guida F;Luongo L;Boccella S;Giordano ME;Romano R;Bellini G;Manzo I;Furiano A;Rizzo A;Imperatore R;Iannotti FA;D'Aniello E;Piscitelli F;Sca Rossi F;Cristino L;Di Marzo V;de Novellis V;Maione S
通讯作者：
Maione S
影响因子：
5
作者：
Jacob, Alexander;Hensley, Lauren K.;Alexander, Jessy J.
通讯作者：
Alexander, Jessy J.
影响因子：
7.6
作者：
Diogenes, A.;Ferraz, C. C. R.;Hargreaves, K. M.
通讯作者：
Hargreaves, K. M.
影响因子：
9.3
作者：
Hernandes MS;D'Avila JC;Trevelin SC;Reis PA;Kinjo ER;Lopes LR;Castro-Faria-Neto HC;Cunha FQ;Britto LR;Bozza FA
通讯作者：
Bozza FA
DOI：
10.1186/cc12746
发表时间：
2013-05-29
期刊：
Critical care (London, England)
影响因子：
--
作者：
Battle CE;Lovett S;Hutchings H
通讯作者：
Hutchings H