A score of non-contrast transthoracic echocardiography to screen patent foramen ovale in patients with embolic stroke of undetermined source.

A score of non-contrast transthoracic echocardiography to screen patent foramen ovale in patients with embolic stroke of undetermined source.
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非对比经胸超声心动图评分用于筛查不明原因栓塞性卒中患者卵圆孔未闭

DOI:
10.1186/s12883-022-02565-w
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发表时间:
2022-02-04
期刊:
影响因子:
2.6
通讯作者:
Cao W
Cao W
中科院分区:
医学4区
文献类型:
--
作者:
Zhang H;Tang H;Wu F;Yu C;Dong Q;Cao W

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背景本研究的目的是开发一种非造影经胸超声心动图(TTE)筛查不明原因栓塞性脑卒中(ESUS)患者卵圆孔未闭(PFO)的评分系统。方法我们对2015年至2018年连续218例最近接受过ESUS的患者进行回顾性分析,这些患者接受了TTE和经颅多普勒(TCD)作为常规检查。 PFO通过TCD气泡试验诊断。选择PFO组和非PFO组之间非对比TTE表现和患者特征的显着性差异作为评分。结果PFO诊断率为35.8%(78/218)。与非 PFO 组相比,中位主动脉根部直径 (ARd) 较大(34 mm vs. 32 mm,p= 0.005),中位峰值 E 波速度(Em)较低(61.5 cm/s vs. 68 cm/s,p= 0.005),二尖瓣反流发生率较低(34.6% vs. 34.6%)。 PFO 组为 50.7%,p= 0.022)。 ARd>33mm 和 Em<72cm/s 是 ROC 分析中预测 PFO 的最佳阈值。包括 TTE 标准(包括 ARd>33 mm、Em < 72 cm/s 且无二尖瓣反流)和无糖尿病史的四点评分系统 (MEAD) 预测 PFO 的曲线下面积为 0.67 (95%CI 0.57–0.72,p< 0.001)。 MEAD 评分≥3 是预测 PFO 的最佳阈值,准确度为 0.64 (95% CI 0.57–0.7),敏感性为 0.65 (95% CI 0.53–0.75),特异性为 0.63 (95% CI 0.55–0.71)。 结论 非造影 TTE 测量的 MEAD 评分可用于选择进行气泡试验的患者TCD 可提高 ESUS 后 PFO 的诊断率。
BackgroundThe aim of this study was to develop a screening score system of non-contrast transthoracic echocardiography (TTE) for patent foramen ovale (PFO) in patients with embolic stroke of undetermined source (ESUS).MethodsWe performed a retrospective analysis of 218 consecutive patients with a recent ESUS from 2015 to 2018, who received TTE and transcranial Doppler (TCD) as routine examinations. PFO was diagnosed by the bubble test of TCD. Significant differences of the non-contrast TTE findings and patient characteristics between PFO group and non-PFO group were selected into a score.ResultsPFO was diagnosed in 35.8% (78/218) of the patients. Compared with non-PFO group, a larger median aortic root diameter (ARd) (34 mm vs. 32 mm,p= 0.005), a lower median peak E wave velocity (Em) (61.5 cm/s vs. 68 cm/s,p= 0.005) and a lower incidence rate of mitral regurgitation (34.6% vs. 50.7%,p= 0.022) were seen in PFO group. ARd>33 mm and Em < 72 cm/s were the best thresholds to predict PFO in ROC analysis. A four-point score system (MEAD) including TTE criteria (including ARd>33 mm, Em < 72 cm/s and without mitral regurgitation) and no history of diabetes predicted PFO with an area under curve of 0.67 (95%CI 0.57–0.72,p< 0.001). MEAD score ≥ 3 was the best threshold to predict PFO with an accuracy of 0.64 (95% CI 0.57–0.7), a sensitivity of 0.65 (95% CI 0.53–0.75) and a specificity of 0.63 (95% CI 0.55–0.71).ConclusionThe MEAD score measured with non-contrast TTE can be used to select patients for bubble test of TCD to increase the diagnostic yield of PFO after ESUS.
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发表时间: 2014-05-22
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