Effect of process parameters on the morphological and mechanical properties of 3D Bioextruded poly(ε-caprolactone) scaffolds
Effect of process parameters on the morphological and mechanical properties of 3D Bioextruded poly(ε-caprolactone) scaffolds
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DOI：
10.1108/13552541211193502
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发表时间：
2012-01-01
影响因子：
3.9
通讯作者：
Chiellini, E.
中科院分区：
文献类型：
--
作者：
Domingos, M.;Chiellini, F.;Chiellini, E.
目的 - 本文旨在报告一项关于工艺参数对使用称为 BioExtruder 的新型挤出系统制造的聚（ε-己内酯）（PCL）形态/机械性能影响的详细研究。设计/方法/方法 - 在这项研究中，作者重点研究了四个参数，即液化器温度（LT）、螺杆旋转速度（SRV）、沉积速度（DV）和切片厚度（ST）。通过采用每个参数的三个不同值来制造支架。通过一系列试验，在保持其他参数不变的同时，迭代地改变一个参数来制造支架。使用扫描电子显微镜 (SEM) 研究结构的形态，同时通过压缩测试评估机械性能。结果 - 实验结果强调了工艺参数对 PCL 支架性能的直接影响。特别是，DV 和 SRV 对道路宽度 (RW) 以及结构的孔隙率和机械行为影响最大。研究限制/含义 - 工艺和设计参数对支架生物反应的影响目前正在研究中。原创性/价值 - 这项工作的成果提供了关于工艺参数对 PCL 支架形态/机械性能影响的重要见解。此外，这种新型挤出系统的潜力和可行性为研究结构特征如何影响支架的特性和性能提供了新的机会，从而能够开发可用于 CAD 系统的集成生物力学模型，以制造用于组织再生的定制结构。
Purpose - This paper aims to report a detailed study regarding the influence of process parameters on the morphological/mechanical properties of poly(epsilon-caprolactone) (PCL) scaffolds manufactured by using a novel extrusion-based system that is called BioExtruder.Design/methodology/approach - In this study the authors focused investigations on four parameters, namely the liquefier temperature (LT), screw rotation velocity (SRV), deposition velocity (DV) and slice thickness (ST). Scaffolds were fabricated by employing three different values of each parameter. Through a series of trials, scaffolds were manufactured varying iteratively one parameter while maintaining constant the other ones. The morphology of the structures was investigated using a scanning electron microscope (SEM), whilst the mechanical performance was assessed though compression tests.Findings - Experimental results highlight a direct influence of the process parameters on the PCL scaffolds properties. In particular, DV and SRV have the highest influence in terms of road width (RW) and consequently on the porosity and mechanical behaviour of the structures.Research limitations/implications - The effect of process and design parameters on the biological response of scaffolds is currently under investigation.Originality/value - The output of this work provides a major insight into the effect of process parameters on the morphological/mechanical properties of PCL scaffolds. Moreover, the potential and feasibility of this novel extrusion-based system open a new opportunity to study how structural features may influence the characteristics and performances of the scaffolds, enabling the development of integrated biomechanical models that can be used in CAD systems to manufacture customized structures for tissue regeneration.