Developing functional magnetic resonance imaging techniques for alert macaque monkeys
Developing functional magnetic resonance imaging techniques for alert macaque monkeys
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DOI：
10.1016/j.ymeth.2005.08.004
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发表时间：
2006-03-01
期刊：
影响因子：
4.8
通讯作者：
Twieg, DB
中科院分区：
文献类型：
--
作者：
Gamlin, PD;Ward, MK;Twieg, DB
功能磁共振成像（fMRI）已迅速发展成为研究人脑的主要非侵入性工具。然而，由于各种技术上的困难，它还没有被广泛采用，用于警觉，受过训练的非人灵长类动物。我们的实验室一直在开发这种功能磁共振成像研究的技术。作为背景，我们首先考虑功能磁共振成像的基本原理，实验设计和后处理。我们讨论了适当的MRI系统硬件和组件进行功能磁共振成像研究在警觉猕猴，和动物的准备和最佳实验所需的行为。最后，我们考虑使用外源性造影剂，动脉自旋标记，更直接的措施，神经激活替代功能磁共振成像技术。(c)2006年爱思唯尔公司All rights reserved.
Functional magnetic resonance imaging (fMRI) has developed rapidly into a major non-invasive tool for studying the human brain. However, due to a variety of technical difficulties, it has yet to be widely adopted for use in alert, trained non-human primates. Our laboratory has been developing techniques for such fMRI studies. As background, we first consider basic principles of fMRI imaging, experimental design, and post-processing. We discuss appropriate MRI system hardware and components for conducting fMRI studies in alert macaques, and the animal preparation and behavior necessary for optimal experiments. Finally, we consider alternative fMRI techniques using exogenous contrast agents, arterial spin labeling, and more direct measures of neural activation. (c) 2006 Elsevier Inc. All rights reserved.