Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy
Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy
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DOI：
10.3390/vetsci6020053
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发表时间：
2019-06-01
影响因子：
2.4
通讯作者：
Marchetti, Veronica
中科院分区：
文献类型：
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作者：
Pierini, Alessio;Lubas, George;Marchetti, Veronica
犬肥大细胞肿瘤（MCT）在预测预后和选择适当的治疗方面呈现出各种具有挑战性的临床行为。本研究调查了一家兽医教学医院 (VTH) 收治的犬的 MCT 发生频率、风险和预后因素。将 98 只患有 MCT 的狗（MCT 组）的品种、年龄、性别和性状态与 2010 年 1 月至 2016 年 1 月从 VTH 临床数据库中获得的 13,077 只狗（VTH 组）的对照组进行比较。MCT 组内的信号、位置、大小、肿块数、溃疡、组织病理学分级、是否存在淋巴结或远处转移进行相互比较以及与结果。拳师犬（OR 7.2）、美国斗牛犬（OR 5.4）、法国斗牛犬（OR 4.4）和拉布拉多猎犬（OR 2.6）的比例过高。 MCT 组明显比 VTH 组年龄大 (p < 0.0001)。与 VTH 组相比，MCT 组中绝育犬（OR 2.1）和绝育雌性（OR 2.3）分别比未绝育的犬和未绝育的雌性占主导地位。溃疡（OR 5.2）和淋巴结转移（OR 7.1）在较大的 MCT 中更常见。溃疡和 MCT > 3 cm 均与淋巴结转移高度相关（OR 24.8）。复发与 MCT 相关死亡相关（OR 10.50，p = 0.0040），后者与较短的生存时间相关（p = 0.0115）。 MCT > 3 cm (p = 0.0040)、淋巴结转移 (p = 0.0234) 或 WHO 分期升高 (p = 0.0158) 的狗的生存时间较短。在特定品种、老年犬和绝育犬中发现 MCT 的频率明显更高。 MCT > 3 cm 和淋巴结或远处转移与较短的生存时间相关。
Canine mast cell tumours (MCTs) present a wide variety of challenging clinical behaviours in terms of predicting the prognosis and choosing appropriate treatment. This study investigated the frequency, risk, and prognostic factors of MCTs in dogs admitted to a single veterinary teaching hospital (VTH). Breed, age, sex, and sexual status in ninety-eight dogs with MCTs (MCT-group) were compared with a control group of 13,077 dogs (VTH-group) obtained from the VTH clinical database from January 2010 to January 2016. Within the MCT-group, signalment, location, size, mass number, ulceration, histopathological grading, presence of lymph node, or distant metastases were compared with each other and with the outcome. Boxers (OR 7.2), American Pit Bull Terriers (OR 5.4), French Bulldogs (OR 4.4) and Labrador Retrievers (OR 2.6) were overrepresented. The MCT-group was significantly older than the VTH-group (p < 0.0001). In comparison with the VTH group, in the MCT-group neutered dogs (OR 2.1) and spayed females (OR 2.3) were predominant compared to intact dogs and intact females, respectively. Ulceration (OR 5.2) and lymph node metastasis (OR 7.1) occurred more frequently in larger MCTs. Both ulceration and MCTs > 3 cm were highly associated with lymph node metastasis (OR 24.8). Recurrence was associated with MCT-related death (OR 10.50, p = 0.0040), and the latter was associated with shorter survival times (p = 0.0115). Dogs with MCTs > 3 cm (p = 0.0040), lymph node metastasis (p = 0.0234), or elevated WHO stage (p = 0.0158) had shorter survival times. A significantly higher frequency of MCTs was found in specific breeds, and in older and neutered dogs. MCTs > 3 cm and lymph node or distant metastases were associated with shorter survival times.