A comparative study on the levels of serum cytokines and cortisol among post-traumatic stress disorder patients of Li and Han ethnicities in Hainan
A comparative study on the levels of serum cytokines and cortisol among post-traumatic stress disorder patients of Li and Han ethnicities in Hainan
复制标题
海南黎族和汉族创伤后应激障碍患者血清细胞因子和皮质醇水平的比较研究
DOI：
10.3760/cma.j.issn.0366-6999.20140738
复制
发表时间：
2014-08-05
影响因子：
6.1
通讯作者：
Jiang Xianglin
中科院分区：
文献类型：
--
作者：
Chen Tao;Guo Min;Jiang Xianglin
背景
创伤后应激障碍（PTSD）是一种由不寻常、具有威胁性或灾难性的心理创伤导致的具有延迟性或慢性起病的精神障碍，是灾后精神和行为障碍的一种重要表现形式。研究表明，白细胞介素 - 6（IL - 6）是一种与PTSD发生相关的细胞因子。本研究旨在通过检测黎族和汉族PTSD患者血清细胞因子白细胞介素 - 2（IL - 2）、白细胞介素 - 6（IL - 6）、白细胞介素 - 8（IL - 8）、肿瘤坏死因子 - α（TNF - α）和皮质醇的水平，来探究细胞因子和种族在PTSD发病机制中的作用。
方法
采用酶联免疫吸附测定（ELISA）法检测30名汉族PTSD患者和30名黎族PTSD患者血清细胞因子白细胞介素 - 2（IL - 2）、白细胞介素 - 6（IL - 6）、白细胞介素 - 8（IL - 8）、肿瘤坏死因子 - α（TNF - α）和皮质醇的水平，并使用PCL - C量表进行评估，同时分别与30名汉族和黎族正常对照者进行比较。
结果
黎族PTSD患者在再体验、回避/麻木和过度警觉症状方面的得分均高于汉族PTSD患者以及黎族和汉族正常对照组。差异具有统计学意义（P
Background Post-traumatic stress disorder (PTSD) is a mental disorder with delayed or chronic onset caused by unusual, threatening, or disastrous psychological trauma, and it is an important manifestation of post-disaster mental and behavioral disorders. Studies have shown that IL-6 is a cytokine associated with PTSD occurrence. This study aimed to explore the role of cytokine and ethnicity in the pathogenesis of PTSD by examining levels of serum cytokines IL-2, IL-6, IL-8, TNF-alpha, and cortisol in PTSD patients of Li and Han ethnic groups.Methods Levels of serum cytokines IL-2, IL-6, IL-8, TNF-alpha, and cortisol were examined by enzyme-linked immunoabsorbent assay (ELISA) method and assessed by PCL-C scale among 30 PTSD patients of Han ethnicity and 30 of Li ethnicity, and compared with 30 normal controls of Han and Li ethnicity, respectively.Results PTSD patients of Li ethnicity scored higher than PTSD patients of Han ethnicity, and normal controls of Li and Han ethnic groups in each of the re-experiencing, avoidance/numbing, and hyperarousal symptoms. The differences reached statistical significance (P