A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation.
A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation.
复制标题
对接受移植评估的肝硬化患者体力活动减少相关因素的前瞻性分析。
DOI：
10.1111/ctr.12602
复制
发表时间：
2015
影响因子：
2.1
通讯作者：
Ge
中科院分区：
文献类型：
--
作者：
DelaCruz,AnnaChristina;Vilchez,Valery;Kim,Sooyeon;Barnes,Benjamin;Ravinuthala,Abhishek;Zanni,Anthony;Galuppo,Roberto;Sourianarayanane,Achuthan;Patel,Trushar;Maynard,Erin;Shah,MalayB;Daily,MichaelF;Uhl,Timothy;Esser,Karyn;Ge
体育活动（PA）与移植后恢复时间的延长有关。握力与移植后的预后有关。目的探讨肝硬化肝移植评估患者PA和握力的预测因素。方法单中心前瞻性分析。结果共纳入100例患者，其中男性占54%，平均年龄53±9岁。肝脏疾病的常见病因为非酒精性脂肪性肝炎（27%）、丙型肝炎（22%）和酒精性肝病（21%）。终末期肝病模型（MELD）平均评分为13.5分。41%的人有吸烟史。93名患者完成了国际体育活动问卷（IPAQ）。中位总PA评分为33代谢当量(MET) - min/周。平均总握力为62.1±22 lb。发现总握力是中低PA的独立预测因子（OR 4.7, 95% CI 1.4-16.2, p = 0.038），吸烟是唯一与握力降低相关的显著因素（OR 3.4, 95% CI 1.4-8, p = 0.005）。结论接受肝移植评估的终末期肝病患者通过IPAQ可降低总PA。发现总握力是肝硬化患者中低PA的重要预测因子。吸烟是握力下降的一个危险因素，握力是肝硬化患者肌肉萎缩的一个重要指标。
BackgroundPhysical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post‐transplant outcomes.AimTo evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation.MethodsSingle‐center, prospective analysis.ResultsOne hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non‐alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end‐stage liver disease (MELD) score was 13.5. Forty‐one percent had a history of smoking. Ninety‐three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)‐min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low–moderate PA (OR 4.7, 95% CI 1.4–16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4–8, p = 0.005).ConclusionsPatients with end‐stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low–moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.