Self-assembled hexasaccharides: Surface characterization of thiol-terminated sugars adsorbed on a gold surface
Self-assembled hexasaccharides: Surface characterization of thiol-terminated sugars adsorbed on a gold surface
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DOI：
10.1021/la960623j
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发表时间：
1996-12-11
期刊：
影响因子：
3.9
通讯作者：
Vasella, A
中科院分区：
文献类型：
--
作者：
Fritz, MC;Hahner, G;Vasella, A
合成了一种巯基封端的乙酰基保护的六糖（AHS），用于从溶液中在金表面沉积自组装单分子膜（SAMs）。使用S射线光电子能谱（XPS）、椭圆偏振法、接触角测量和成像飞行时间二次离子质谱（iToF-SIMS）来确定覆盖率、均匀性、化学组成、膜厚度和膜生长动力学。在AHS吸附到表面上之后以及从溶液中吸附之前，进行分子的脱保护，即用羟基取代乙酰氧基。测定了所得膜的化学组成、膜厚度、分子密度和表面官能团的性质。从溶液中的脱保护分子（DHS）的吸附被发现导致吸附物种的密度较高。
A thiol-terminated hexasaccharide, protected with acetyl groups (AHS) was synthesized for the purpose of depositing self-assembled monolayers (SAMs) from solution onto gold surfaces. S-ray photoelectron spectroscopy (XPS), ellipsometry, contact angle measurements, and imaging time-of-flight secondary ion mass spectroscopy (iToF-SIMS) were used to determine coverage, homogeneity, chemical composition, film thicknesses, and kinetics of film growth. Deprotection of the molecules, i.e. replacing acetoxy groups by hydroxyl groups, was performed following adsorption of AHS onto the surface, as well as prior to adsorption from solution. The chemical composition of the resulting films, the film thickness, the density of molecules, and the nature of the surface functional groups were determined. Adsorption of the deprotected molecules (DHS) from solution was found to lead to a higher density of adsorbed species.