CYTOGENETIC DAMAGE INDUCED IN HUMAN-LYMPHOCYTES BY LOW-DOSES OF CO-60 GAMMA-RAYS DELIVERED AT HIGH AND LOW-DOSE RATES
CYTOGENETIC DAMAGE INDUCED IN HUMAN-LYMPHOCYTES BY LOW-DOSES OF CO-60 GAMMA-RAYS DELIVERED AT HIGH AND LOW-DOSE RATES
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DOI：
10.3109/02841868609136393
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发表时间：
1986-03-01
期刊：
影响因子：
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通讯作者：
FABRY, L
中科院分区：
文献类型：
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作者：
FABRY, L
研究了低剂量60Co γ射线急性或低剂量率（0.1或0.03 Gy/h）照射后人外周血淋巴细胞的染色体畸变。为避免二次分裂细胞评分，对培养时间为44 ~ 46小时的细胞进行染色体分析，并采用最大似然法分析剂量相关诱导畸变的情况。在所有情况下，双心性的诱导都可以用线性二次剂量响应模型（Y=aD+bD2）很好地描述，在低剂量率下获得的数据同样可以很好地拟合线性方程。根据早先关于像差形成机制的发现，源自单一电离轨迹的两个损伤必须在大约5小时的时间内产生，才能相互作用并产生双心像差，这可以解释在低剂量率下二次项的减少，因为最高剂量是在5小时以上的时间内给予的。
Chromosomal aberrations were investigated in human peripheral blood lymphocytes after exposure to low doses of 60Co gamma rays delivered acutely or at low dose rates (0.1 or 0.03 Gy/h). Chromosome analysis was performed in cells collected after a 44 to 46 hour culture time in order to avoid scoring of second division cells, and the dose-related induction of aberrations was analyzed by the maximum likelihood method. In all cases, the induction of dicentrics was well described by a linear-quadratic dose response model (Y=aD+bD2), the data obtained at a low dose rate being equally well fitted to a linear equation. According to earlier findings on the mechanisms of aberration formation, the two lesions originating from single ionizing tracks have to be produced within a period of approximately 5 hours, in order to interact and to give rise to dicentric aberrations, which could explain the decrease in the quadratic term at the low dose rate since the highest doses were delivered over a period of more than 5 hours.