Variation in candidate genes CLOCK and ADCYAP1 does not consistently predict differences in migratory behavior in the songbird genus Junco.
Variation in candidate genes CLOCK and ADCYAP1 does not consistently predict differences in migratory behavior in the songbird genus Junco.
复制标题
DOI：
10.12688/f1000research.2-115.v1
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ketterson ED
中科院分区：
文献类型：
--
作者：
Peterson MP;Abolins-Abols M;Atwell JW;Rice RJ;Milá B;Ketterson ED
最近的研究探索动物迁徙变异的分子遗传基础，发现了两个基因（CLOCK和ADCYAP 1）的多态性，这两个基因与昼夜节律有关，并与个体和种群之间的迁徙倾向和物候学相关。然而，这些初步研究的结果是混合的，需要更多的数据来评估调节迁移生物学的分子机制的普遍性和多样性。我们在15个种群的两个物种的鸟类属Junco，北美血统，其中多个最近分化的亚种和种群范围从定居到长距离移民的时钟和ADCYAP1测序。我们发现，无论是CLOCK还是ADCYAP 1，等位基因长度与整个属的迁移状态之间都没有一致的关联。然而，在两个亚种组中，迁移距离较长的种群平均具有较长的CLOCK等位基因。此外，ADCYAP 1等位基因长度和迁移躁动（zugunruhe）之间存在正相关关系，其中两个圈养种群之一的研究结果类似于先前报道的圈养黑顶莺（Sylvia atricapilla）。我们的结论是，虽然ADCYAP 1和CLOCK都可能与某些种群或物种内或之间的迁移倾向相关，但之前确定的迁移行为和序列变体之间的关系无法轻易地在分类群中推广。
Recent studies exploring the molecular genetic basis for migratory variation in animals have identified polymorphisms in two genes ( CLOCK and ADCYAP1) that are linked to circadian rhythms and correlate with migratory propensity and phenology among individuals and populations. Results from these initial studies are mixed, however, and additional data are needed to assess the generality and diversity of the molecular mechanisms that regulate the biology of migration. We sequenced CLOCK and ADCYAP1 in 15 populations across the two species of the avian genus Junco, a North American lineage in which multiple recently diverged subspecies and populations range from sedentary to long-distance migrants. We found no consistent associations between allele length and migratory status across the genus for either CLOCK or ADCYAP1. However, within two subspecies groups, populations that migrate longer distances have longer CLOCK alleles on average. Additionally, there was a positive relationship between ADCYAP1 allele length and migratory restlessness (zugunruhe) among individuals within one of two captive populations studied—a result similar to those reported previously within captive blackcaps ( Sylvia atricapilla). We conclude that, while both ADCYAP1 and CLOCK may correlate with migratory propensity within or among certain populations or species, previously identified relationships between migratory behavior and sequence variants cannot be easily generalized across taxa.