THE ANTI-INFLAMMATORY ACTION OF NEPITRIN, A FLAVONOID
THE ANTI-INFLAMMATORY ACTION OF NEPITRIN, A FLAVONOID
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DOI：
10.1007/bf01965393
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
AGARWAL, OP
中科院分区：
文献类型：
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作者：
AGARWAL, OP
用大鼠急性和慢性炎症模型研究了黄酮类化合物奈匹林（5，3“，4”-三羟基-6-甲氧基黄酮）的抗炎作用。Nepitrin在炎症的渗出期和增殖期具有显著的抗炎活性。奈匹林的这种作用可能是由于其抗缓激肽和抗血管紧张素作用。Nepitrin也具有解热和弱镇痛活性。Nepitrin可用作抗炎剂和抗关节炎剂。
The antiinflammatory efficacy of nepitrin (5,3''4''-trihydroxy-6-methoxy flavone), a flavonoid, was investigated in acute and chronic models of inflammation in rats. Nepitrin possessed significant antiinflammatory activity in the exudative and proliferative phases of inflammation. This action of nepitrin could be due to its antibradykinin and antiangiotensin action. Nepitrin also possessed antipyretic and weak analgesic activity. Nepitrin may be useful as an antiinflammatory and antiarthritic agent.