Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos
Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos
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DOI：
10.1161/01.res.0000100389.57520.1a
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发表时间：
2003-10-31
影响因子：
20.1
通讯作者：
Izumo, S
中科院分区：
文献类型：
--
作者：
Ishiwata, T;Nakazawa, M;Izumo, S
遗传和表观遗传因素，如血流动力学异常，影响心脏形态发生和先天性心脏病的发病机制。舒张功能是心脏功能的重要决定因素，评估胚胎舒张功能的工具对于评估心脏性能非常有价值。使用心室肌结构的组织学测量，多普勒评估心室流入速度，心室压力的直接测量，我们研究了小鼠胚胎心室舒张功能的发育变化，从胚胎天9.5至19.5。回归分析显示，A波峰值速度（被动顺应性指标）与右心室（RV）心肌小梁面积相关（r（2）= 0.92，P
Both genetic and epigenetic factors, such as abnormal hemodynamics, affect cardiac morphogenesis and the pathogenesis of congenital heart disease. Diastolic function is an important determinant of cardiac function, and tools for evaluating diastolic function in the embryo would be very valuable for assessment of cardiac performance. Using histological measurements of ventricular myoarchitecture, Doppler assessment of ventricular inflow velocities, and direct measurement of ventricular pressure, we investigated developmental changes of ventricular diastolic function in the mouse embryos from embryonic days 9.5 to 19.5. Regression analysis showed that peak velocity of A wave (an index of passive compliance) correlated with the area of trabecular myocardium in right ventricle (RV) (r(2)=0.92, P