twilight; a Bioconductor package for estimating the local false discovery rate
twilight; a Bioconductor package for estimating the local false discovery rate
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DOI：
10.1093/bioinformatics/bti436
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发表时间：
2005-06-15
期刊：
影响因子：
5.8
通讯作者：
Spang, R
中科院分区：
文献类型：
--
作者：
Scheid, S;Spang, R
Twilight是一个Bioconductor兼容软件包，用于分析差异表达基因的统计学意义。它基于局部错误发现率（FDR）的概念，这是常用的全局FDR的推广。Twilight实现了用于估计我们早期工作中介绍的局部FDR的启发式搜索算法。除了原始的显著性测量之外，它还产生诊断图，这些图提供了对基因间差异表达程度的洞察。
Twilight is a Bioconductor compatible package for analysing the statistical significance of differentially expressed genes. It is based on the concept of the local false discovery rate (FDR), a generalization of the frequently used global FDR. twilight implements the heuristic search algorithm for estimating the local FDR introduced in our earlier work. In addition to the raw significance measures, it produces diagnostic plots, which provide insight into the extent of differential expression across genes.