The VCD Mouse Model of Menopause and Perimenopause for the Study of Sex Differences in Cardiovascular Disease and the Metabolic Syndrome
The VCD Mouse Model of Menopause and Perimenopause for the Study of Sex Differences in Cardiovascular Disease and the Metabolic Syndrome
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DOI：
10.1152/physiol.00057.2014
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发表时间：
2016-07-01
期刊：
影响因子：
8.4
通讯作者：
Hoyer, P. B.
中科院分区：
文献类型：
--
作者：
Brooks, H. L.;Pollow, D. P.;Hoyer, P. B.
在女性中，更年期，月经周期的停止，与几种疾病的风险增加有关，如心血管疾病，骨质疏松症，糖尿病，代谢综合征和卵巢癌。大多数妇女进入更年期通过卵巢功能逐渐减少几年（围绝经期）和保留残余卵巢组织。绝经（啮齿类动物卵巢衰竭）的VCD小鼠模型是一种卵泡耗竭、卵巢完整的动物，更接近于人类通过围绝经期进入绝经后阶段的自然进展。本文就VCD模型的生理学参数及其在绝经后疾病机制研究中的应用进行综述，重点介绍近年来在糖尿病肾病、代谢综合征和高血压等方面的小鼠研究。
In females, menopause, the cessation of menstrual cycling, is associated with an increase in risk for several diseases such as cardiovascular disease, osteoporosis, diabetes, the metabolic syndrome, and ovarian cancer. The majority of women enter menopause via a gradual reduction of ovarian function over several years (perimenopause) and retain residual ovarian tissue. The VCD mouse model of menopause (ovarian failure in rodents) is a follicle-deplete, ovary-intact animal that more closely approximates the natural human progression through perimenopause and into the postmenopausal stage of life. In this review, we present the physiological parameters of how to use the VCD model and explore the VCD model and its application into the study of postmenopausal disease mechanisms, focusing on recent murine studies of diabetic kidney disease, the metabolic syndrome, and hypertension.