Cutting edge: Major CD8 T cell response to live bacillus Calmette-Guerin is mediated by CD1 molecules
Cutting edge: Major CD8 T cell response to live bacillus Calmette-Guerin is mediated by CD1 molecules
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DOI：
10.4049/jimmunol.170.11.5345
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发表时间：
2003-06-01
影响因子：
4.4
通讯作者：
Sugita, M
中科院分区：
文献类型：
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作者：
Kawashima, T;Norose, Y;Sugita, M
MHC I类限制性CD8(+)T细胞是小鼠抵抗分枝杆菌感染的宿主防御的重要组成部分，但在人类中往往很难识别CDS T细胞反应。人类第1组CD1分子(CD1a、-b、-c)介导分枝杆菌衍生的脂类和糖脂AGS向CD8(+)T细胞的MHC非依赖性递呈，它们在细胞内的定位有助于有效地监测吞噬小体驻留的分枝杆菌。在这里，我们显示卡介苗(BCG)免疫的受试者包含一个重要的CD8(+)T细胞循环池，识别假发感染的DO的方式依赖于CD1，但不依赖于MHC。这些受CM限制的T细胞有效地检测到活的而不是死亡的卡介苗，并产生干扰素-γ，这是一种重要的细胞因子，用于保护免受分枝杆菌感染。这些结果强调，脂质反应性CD8(+)T细胞可能有助于宿主对分枝杆菌感染的防御。
MHC class I-restricted CD8(+) T cells are a crucial component of the host defense against mycobacterial infection in mice, but it has often proved very difficult to identify the CDS T cell response in humans. Human group 1 CD1 molecules (CD1a, -b, -c) mediate MHC-independent presentation of mycobacteria-derived lipid and glycolipid Ags to CD8(+) T cells, and their intracellular localization to the endocytic system may favor efficient monitoring of phagosome-resident mycobacteria. Here, we show that bacillus Calmette-Guerin (BCG)-immunized subjects contain a significant circulating pool of CD8(+) T cells that, recognize WIG-infected DO in a CD1-dependent, but MHC-independent, manner. These CM-restricted T cells efficiently detected live, rather than dead, BCG and produced IFN-gamma, an important cytokine for protection against mycobacterial infection. These results emphasize that lipid-reactive CD8(+) T cells may contribute to host defense against mycobacterial infection.