Recent advances in HIV-associated chronic lung disease clinical research.
Recent advances in HIV-associated chronic lung disease clinical research.
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DOI：
10.1097/coh.0000000000000679
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发表时间：
2021-05-01
影响因子：
4.1
通讯作者：
Kunisaki KM
中科院分区：
文献类型：
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作者：
Kunisaki KM
重点介绍最近发表的针对成年 HIV 感染者 (PWH) 慢性肺病的临床研究。慢性肺病是纽约住院感染者中最常见的合并症，也是加拿大门诊感染者中第二常见的疾病。感染者患慢性阻塞性肺疾病 (COPD) 的风险升高已得到广泛认可，但感染者患哮喘的风险也较高，且哮喘结果更差。对肺结构和功能的扩展评估，例如单次呼吸一氧化碳扩散能力 (DLCO)、呼出一氧化氮 (FeNO) 和胸部计算机断层扫描 (CT)，为了解 HIV 对肺部的影响提供了新的见解。新的生物标志物分析正在出现，但需要进一步的研究来验证感染者慢性肺病的预测生物标志物。针对感染者慢性肺病的临床试验数量很少。慢性肺病是感染者中常见且影响较大的合并症。未来的研究应该收集更全面的肺部评估，例如 DLCO、FeNO 和胸部 CT，以便更好地对 HIV 肺部紊乱进行表型分析。迫切需要进行临床试验来减轻感染者慢性肺病日益增加的负担。
To highlight recently published, clinically-focused research on chronic lung disease in adult persons with HIV (PWH). Chronic lung disease was the most common comorbidity in hospitalized PWH in New York and second-most common condition in ambulatory PWH in Canada. The elevated risk of chronic obstructive pulmonary disease (COPD) in PWH has been widely recognized, but PWH are also at higher risk for asthma and worse asthma outcomes. Expanded assessments of lung structure and function, such as single-breath diffusing capacity of carbon monoxide (DLCO), exhaled nitric oxide (FeNO), and chest computed tomography (CT) have provided new insights into HIV effects on the lungs. New biomarker analyses are emerging, but further studies are needed to validate predictive biomarkers for chronic lung disease in PWH. Clinical trials addressing chronic lung disease in PWH are few in number. Chronic lung disease is a common and high-impact comorbidity among PWH. Future studies should collect more comprehensive lung assessments such as DLCO, FeNO, and chest CT in order to better phenotype lung derangements in HIV. Clinical trials are desperately needed to reduce the rising burden of chronic lung disease in PWH.