Dietary supplementation with monosodium glutamate is safe and improves growth performance in postweaning pigs
Dietary supplementation with monosodium glutamate is safe and improves growth performance in postweaning pigs
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DOI：
10.1007/s00726-012-1420-x
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发表时间：
2013-03-01
期刊：
影响因子：
3.5
通讯作者：
Wu, Guoyao
中科院分区：
文献类型：
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作者：
Rezaei, Reza;Knabe, Darrell A.;Wu, Guoyao
由于饲料消耗量低，断奶仔猪对谷氨酸的日粮摄入量明显减少。本研究旨在探讨日粮中添加谷氨酸单钠(MSG)对断奶仔猪的安全性和有效性。21日龄断奶仔猪，饲喂玉米和豆粕基础日粮，添加0、0.5、1、2和4%的味精(n=25)。在基础日粮中添加味精，但不添加玉米淀粉。于42日龄(断奶后21d)，每组25头猪分别于饲喂后1h和4h从颈静脉取血10m L进行血液学和临床生化检查，然后处死6头猪，取组织进行组织病理学检查。日粮中添加0~2%的味精不影响采食量，添加4%的味精比添加0%的味精降低了15%的采食量。与对照组相比，日粮中添加1%、2%和4%的味精可提高断奶仔猪血浆谷氨酸、谷氨酰胺和其他氨基酸(包括赖氨酸、蛋氨酸、苯丙氨酸和亮氨酸)的浓度、日增重和饲料效率。在断奶后第7天，日粮中添加1-4%的味精也能提高空肠绒毛高度、DNA含量和抗氧化能力。补充味精可降低断奶后第一周的腹泻发生率，且呈剂量依赖关系。标准血液学和临床化学测试中的所有变量，以及大体和微观结构，在五组猪之间没有差异。这些结果表明，日粮中添加高达4%的味精是安全的，并能改善断奶仔猪的生长性能。
Dietary intake of glutamate by postweaning pigs is markedly reduced due to low feed consumption. This study was conducted to determine the safety and efficacy of dietary supplementation with monosodium glutamate (MSG) in postweaning pigs. Piglets were weaned at 21 days of age to a corn and soybean meal-based diet supplemented with 0, 0.5, 1, 2, and 4 % MSG (n = 25/group). MSG was added to the basal diet at the expense of cornstarch. At 42 days of age (21 days after weaning), blood samples (10 mL) were obtained from the jugular vein of 25 pigs/group at 1 and 4 h after feeding for hematological and clinical chemistry tests; thereafter, pigs (n = 6/group) were euthanized to obtain tissues for histopathological examinations. Feed intake was not affected by dietary supplementation with 0-2 % MSG and was 15 % lower in pigs supplemented with 4 % MSG compared with the 0 % MSG group. Compared with the control, dietary supplementation with 1, 2 and 4 % MSG dose-dependently increased plasma concentrations of glutamate, glutamine, and other amino acids (including lysine, methionine, phenylalanine and leucine), daily weight gain, and feed efficiency in postweaning pigs. At day 7 postweaning, dietary supplementation with 1-4 % MSG also increased jejunal villus height, DNA content, and antioxidative capacity. The MSG supplementation dose-dependently reduced the incidence of diarrhea during the first week after weaning. All variables in standard hematology and clinical chemistry tests, as well as gross and microscopic structures, did not differ among the five groups of pigs. These results indicate that dietary supplementation with up to 4 % MSG is safe and improves growth performance in postweaning pigs.